Beginning at the intersection of 4th Street N (US 92 and SR 687 and 5th Avenue N in St. Petersburg, Florida, it runs west of US 19 near the Gulf coast passing through the cities of Seminole, Clearwater, Dunedin and Tarpon Springs before ending at US 19 in Holiday, Pasco County, Florida. It is also the unsigned State Road 595 throughout the entire route. It also runs along much of the Pinellas Trail.
U.S. Route 19 Business (US 19 Business) in Albany, Georgia is co-signed with US BUS 82 throughout its entire length. It begins at Exit 2B on the Liberty Expressway and joins westbound US BUS 82. From there US BUS 19/82 turn north at Georgia State Route 234, and joins a concurrency with that route until both business routes end at Exit 6 which is the west end of the US 19/82 overlap, and the east end of the US 82/GA 234 overlap.
U.S. Route 19 Business is a 3 miles (4.8 km) business route established in 1980 that replaced the original US 19 routing through the city of Murphy, along Hiwassee Street, Valley River Avenue, Hill Street, Andrews Road and Pleasant Valley Road.
U.S. Route 19 Truck (US 19 Truck) is a truck route route of US 19 located in Western North Carolina. Its routing follows the former routing of US 19A (1976-1983) and US 19 Bypass (1983-1987) along the Great Smoky Mountains Expressway, between Bryson City and Lake Junaluska. Signage appears only at the end points, with no reassurance signs along route.
U.S. Route 19 Connector (US 19 Conn) is a .72-mile (1.16 km) connector route established on October 2011, that connect US 19 (Main Street) with US 74 (Great Smoky Mountains Expressway). Also known as Veterans Boulevard, it was upgraded to primary status because of real need of maintenance and Swain County's secondary route budget was unable to support it. The route is an undivided four-lane the entire length and serves as the main entrance to Bryson City.
U.S. Route 19 Business (US 19 Bus), established in 1960, is a 2.3 miles (3.7 km) business route currently starts on Haywood Road then go north on I-26/I-240 (exit 2) back to the main US 19 (exit 3). Historically, US 19 Business continued along Haywood Road, connecting to Clingman Avenue and then to Patton Avenue/US 19. In 1961, it extended over Patton Avenue through downtown Asheville when US 19 moved onto the East-West Freeway. In 1962, it was rerouted to its current alignment from Haywood Road to Hanover Street (now I-26/I-240). It is co-signed with US 23 Bus.
U.S. Route 19 Business, established on September 1967, this 5.5 miles (8.9 km) business route follows the original US 19 mainline through the city of Weaverville. The business loop is clearly marked along the route, though the freeway bypass (I-26/US 19/US 23) does not mention it. It starts from exit 23 interchange (with a brief overlap with US 25), then goes north along Weaverville Road and Main Street; it reconnects with the freeway at the exit 18 interchange via Clarks Chapel Road/Monticello Road.
U.S. Route 19 Alternate was a former segment of US 19 that ran from Bayonte Point to Brooksville, Florida, which only existed for one year. It ran along what is today State Road 52 from Bayonet Point to Gowers Corner, and then turned north along US 41 into Brooksville.
U.S. Route 19 Alternate (US 19A) was established in 1947, replacing part of NC 28, between Ela and Cherokee, and all of NC 293 between Cherokee and Lake Junaluska, via Soco Gap. In 1948, US 19 and US 19A swapped routes.
U.S. Route 19 Alternate (US 19A) was established in 1948 when US 19 swapped routes with the previous US 19A between Ela and Lake Junaluska, via Soco Gap. US 19A followed the old alignment of US 19 from Ela, through Dillsboro, Sylva and Waynesville, to Lake Junaluska. Between 1954-1957, US 19A/US 23 was placed onto current routing bypassing Balsam. Between 1958-1962, US 19A/US 23 was placed on one-way streets through Sylva; northbound via Main Street and southbound via Mill Street. In 1967, US 19A/US 23 was rerouted on new freeway bypass west of Waynesville; its old alignment becoming US 23 Bus. In 1974, US 19A was placed on new freeway bypass north of Dillsboro and Sylva; its old alignment becoming US 23 Bus. In 1975, the relocation around Sylva was submitted to AASHTO for approval, but was denied by the subcommittee; despite the denial, NCDOT left signage as is. In 1976, US 19A was placed on new freeway bypass east of Bryson City, from Alarka Road to US 441; its old alignment from Ela to Whittier was downgraded to secondary road. In 1982, NCDOT submitted a request to AASHTO to switch US 19 and US 19A between Bryson City and Lake Junaluska; but was later withdrawn before the vote. In 1983, US 19A was redesignated US 19 Bypass; despite the change, signage along the route maintained US 19A during and after US 19 Bypass was also eliminated in 1987.
U.S. Route 19 Bypass (US 19 By-Pass) was established in 1983 as a redesignation of US 19A between Bryson City and Lake Junaluska; this also coincide the establishment of the Great Smoky Mountains Expressway. In 1987, US 19 Bypass was eliminated in favor for US 74, which was extended west of Asheville the prior year. Despite being officially US 19 Bypass, signage along the route remained US 19A throughout, with some signs still marking the route til the mid-1990s.[not in citation given]