In Toledo, Oregon, U.S. Route 20 Business runs from an intersection with the main highway west of Toledo on the Toledo Frontage Road and 5th Street through Toledo and again on the Toledo Frontage Road to an intersection with the main highway east of Toledo. Business 20 in Toledo is also called Sharon Branstiter Memorial Drive, in memory of Toledo's former mayor.
In Bend, Oregon, U.S. Route 20 Business runs from an intersection with the main highway north of Bend, south on East 1st Street, Deschutes Place, and Wall Street to Newport Avenue, concurrent with U.S. 97 Business, and then east on Newport Avenue and Greenwood Avenue to the main highway concurrent with East 3rd Avenue in Bend.
U.S. Route 20 Business in the Sioux City area originates in Nebraska, at the junction of Dakota Avenue and Interstate 129 in South Sioux City. US 20 Bus. follows US 20's old alignment through South Sioux City before crossing into Iowa concurrently with U.S. Route 77. US 20 Bus. then joins with Interstate 29, for a very short distance before exiting onto Virginia Street and then Gordon Drive. U.S. 20 Bus. westbound traffic does not join I29, but skips it though a system of ramps. The route then follows Gordon Drive through central Sioux City to the US 20/US 75 bypass, where it rejoins US 20. US 20 Bus. in Sioux City is known officially as Iowa Highway 12, though Iowa 12 is signed as ending at Interstate 29 in western Sioux City.
In the Fort Dodge area, U.S. Route 20 Business begins at the western end of the current US 20 expressway near Moorland and follows US 20's former route through the city via Kenyon Road and 5th Avenue South. Just east of Fort Dodge's eastern city limits, US 20 Bus. turns south on Webster County Road P59, passing through several gypsum mining areas before rejoining the US 20 expressway in Coalville.
The longest Business U.S. Route 20 in Illinois runs 21 miles (34 km) from just west of Rockford to just east of Belvidere. The route begins just west of Weldon Road and runs as State Street into downtown Rockford, where it is split into two one-way streets (Chestnut Street, Walnut Street and First Avenue for eastbound traffic, Jefferson Street and Kilburn Avenue for westbound traffic). The route continues east along State Street all the way through Rockford and becomes a two-lane highway between Rockford and Belvidere. Business 20 is then routed in an outer loop around the city of Belvidere before merging back with US 20 near Genoa Road and Interstate 90 (Jane Addams Memorial Tollway).
Business U.S. 20 follows the former route of U.S. 20 through South Bend and Mishawaka, generally along Colfax Avenune and McKinley Avenue/McKinley Highway. Signage is inconsistent along parts of the route.
US 20 and US 20A are never more than five miles (8 km) apart for the entire 50-mile (80 km) stretch through the Ohio farm country, with the main line of US 20 taking the more northerly route.
The current US 20A was designated U.S. Route 20S in 1932, which replaced State Route 271 which had run from US 20 south to Montpelier, truncated Ohio State Route 107, joined Ohio State Route 2, and followed a road formerly not on the state highway system through most of Lucas County. It became US 20A in 1935. US 20A was moved to its current location along SR 15 from State Routes 576 and 107 in 1964. (107 then reclaimed some of the miles that had been taken from it in 1932.)
U.S. Route 20 Truck is a truck route of US 20 in Silver Creek, New York. The road begins at an intersection with US 20 in Silver Creek, goes along Central Avenue for a short time and merges in with NY 5. The two become concurrent for another mile on Howard Street where US 20 Truck ends at an intersection with US 20.
Bypass U.S. 20 was the designation for the portion of the St. Joseph Valley Parkway during the period when it was only open between US 31 south of South Bend and US 20 to the west. When the freeway was extended north and US 31 was rerouted onto it, the Bypass 20 designation was removed. When the freeway was completed to the east reconnecting to US 20, the mainline US 20 designation was transferred to it, rather than the Bypass 20 designation being reapplied to it.
From 1971 to 1983, U.S. Route 20 Alternate ran concurrently with the current Alternate U.S. 6 from their common eastern terminus in the Ohio City neighborhood in Cleveland to U.S. 20/SR 113 in Rocky River.