Ubiquitin A-52 residue ribosomal protein fusion product 1

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Ubiquitin A-52 residue ribosomal protein fusion product 1
Protein UBA52 PDB 1aar.png
PDB rendering based on 1aar.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols UBA52 ; CEP52; HUBCEP52; L40; RPL40
External IDs OMIM191321 HomoloGene68307 GeneCards: UBA52 Gene
RNA expression pattern
PBB GE UBA52 221700 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7311 22186
Ensembl ENSG00000221983 ENSMUSG00000055553
UniProt P62987 P62984
RefSeq (mRNA) NM_001033930 NM_019883
RefSeq (protein) NP_001029102 NP_063936
Location (UCSC) Chr 19:
18.68 – 18.69 Mb
Chr 4:
3.97 – 3.97 Mb
PubMed search [1] [2]

60S ribosomal protein L40 (RPL40) is a protein that in humans is encoded by the UBA52 gene.[1][2]

Function[edit]

Ubiquitin is a highly conserved nuclear and cytoplasmic protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N-terminus and ribosomal protein L40 at the C-terminus, a C-terminal extension protein (CEP). Multiple processed pseudogenes derived from this gene are present in the genome.[2]

Clinical significance[edit]

The cell's ribosomal protein L40 (rpL40), a part of the large 60S subunit. rpL40 is used by certain RNA viruses to translate messenger RNAs (mRNAs) into proteins while few host mRNAs require rpL40. Hence targeting this protein may provide a means to combat viral infections with minimum side effects to the host.[3]

References[edit]

  1. ^ Webb GC, Baker RT, Coggan M, Board PG (Jun 1994). "Localization of the human UBA52 ubiquitin fusion gene to chromosome band 19p13.1-p12". Genomics 19 (3): 567–9. doi:10.1006/geno.1994.1108. PMID 8188300. 
  2. ^ a b "Entrez Gene: UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1". 
  3. ^ Lee AS, Burdeinick-Kerr R, Whelan SP (November 2012). "A ribosome-specialized translation initiation pathway is required for cap-dependent translation of vesicular stomatitis virus mRNAs". Proc. Natl. Acad. Sci. U.S.A. doi:10.1073/pnas.1216454109. PMID 23169626. Lay summaryHarvard Medical School. 

Further reading[edit]