UBE2A

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Ubiquitin-conjugating enzyme E2A
Protein UBE2A PDB 1jas.png
PDB rendering based on 1jas.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols UBE2A ; HHR6A; MRXS30; MRXSN; RAD6A; UBC2
External IDs OMIM312180 MGI102959 HomoloGene68308 GeneCards: UBE2A Gene
EC number 6.3.2.19
RNA expression pattern
PBB GE UBE2A 201899 s at tn.png
PBB GE UBE2A 201898 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7319 22209
Ensembl ENSG00000077721 ENSMUSG00000016308
UniProt P49459 Q9Z255
RefSeq (mRNA) NM_003336 NM_019668
RefSeq (protein) NP_003327 NP_062642
Location (UCSC) Chr X:
118.71 – 118.72 Mb
Chr X:
36.87 – 36.88 Mb
PubMed search [1] [2]

Ubiquitin-conjugating enzyme E2 A is a protein that in humans is encoded by the UBE2A gene.[1][2]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Multiple alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.[2]

Interactions[edit]

UBE2A has been shown to interact with RAD18[3][4] and P53.[5]

References[edit]

  1. ^ Koken MH, Smit EM, Jaspers-Dekker I, Oostra BA, Hagemeijer A, Bootsma D, Hoeijmakers JH (May 1992). "Localization of two human homologs, HHR6A and HHR6B, of the yeast DNA repair gene RAD6 to chromosomes Xq24-q25 and 5q23-q31". Genomics 12 (3): 447–53. doi:10.1016/0888-7543(92)90433-S. PMID 1559696. 
  2. ^ a b "Entrez Gene: UBE2A ubiquitin-conjugating enzyme E2A (RAD6 homolog)". 
  3. ^ Xin, H; Lin W, Sumanasekera W, Zhang Y, Wu X, Wang Z (July 2000). "The human RAD18 gene product interacts with HHR6A and HHR6B". Nucleic Acids Res. (ENGLAND) 28 (14): 2847–54. doi:10.1093/nar/28.14.2847. PMC 102657. PMID 10908344. 
  4. ^ Tateishi, S; Sakuraba Y, Masuyama S, Inoue H, Yamaizumi M (July 2000). "Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (14): 7927–32. doi:10.1073/pnas.97.14.7927. ISSN 0027-8424. PMC 16647. PMID 10884424. 
  5. ^ Lyakhovich, Alex; Shekhar Malathy P V (April 2003). "Supramolecular complex formation between Rad6 and proteins of the p53 pathway during DNA damage-induced response". Mol. Cell. Biol. (United States) 23 (7): 2463–75. doi:10.1128/MCB.23.7.2463-2475.2003. ISSN 0270-7306. PMC 150718. PMID 12640129. 

Further reading[edit]