UBE2B

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Ubiquitin-conjugating enzyme E2B
Protein UBE2B PDB 1jas.png
PDB rendering based on 1jas.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols UBE2B ; E2-17kDa; HHR6B; HR6B; RAD6B; UBC2
External IDs OMIM179095 MGI102944 HomoloGene101298 GeneCards: UBE2B Gene
EC number 6.3.2.19
RNA expression pattern
PBB GE UBE2B 202334 s at tn.png
PBB GE UBE2B 202333 s at tn.png
PBB GE UBE2B 202335 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7320 22210
Ensembl ENSG00000119048 ENSMUSG00000020390
UniProt P63146 P63147
RefSeq (mRNA) NM_003337 NM_009458
RefSeq (protein) NP_003328 NP_033484
Location (UCSC) Chr 5:
133.71 – 133.73 Mb
Chr 11:
51.99 – 52 Mb
PubMed search [1] [2]

Ubiquitin-conjugating enzyme E2 B is a protein that in humans is encoded by the UBE2B gene.[1][2]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution.[2]

Interactions[edit]

UBE2B has been shown to interact with RAD18.[3][4]

References[edit]

  1. ^ Koken MH, Smit EM, Jaspers-Dekker I, Oostra BA, Hagemeijer A, Bootsma D, Hoeijmakers JH (May 1992). "Localization of two human homologs, HHR6A and HHR6B, of the yeast DNA repair gene RAD6 to chromosomes Xq24-q25 and 5q23-q31". Genomics 12 (3): 447–53. doi:10.1016/0888-7543(92)90433-S. PMID 1559696. 
  2. ^ a b "Entrez Gene: UBE2B ubiquitin-conjugating enzyme E2B (RAD6 homolog)". 
  3. ^ Xin, H; Lin W, Sumanasekera W, Zhang Y, Wu X, Wang Z (July 2000). "The human RAD18 gene product interacts with HHR6A and HHR6B". Nucleic Acids Res. (ENGLAND) 28 (14): 2847–54. doi:10.1093/nar/28.14.2847. PMC 102657. PMID 10908344. 
  4. ^ Tateishi, S; Sakuraba Y, Masuyama S, Inoue H, Yamaizumi M (July 2000). "Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 97 (14): 7927–32. doi:10.1073/pnas.97.14.7927. ISSN 0027-8424. PMC 16647. PMID 10884424. 

Further reading[edit]