UBE2C

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Ubiquitin-conjugating enzyme E2C
Protein UBE2C PDB 1i7k.png
PDB rendering based on 1i7k.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols UBE2C ; UBCH10; dJ447F3.2
External IDs OMIM605574 MGI1915862 HomoloGene5096 GeneCards: UBE2C Gene
EC number 6.3.2.19
RNA expression pattern
PBB GE UBE2C 202954 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 11065 68612
Ensembl ENSG00000175063 ENSMUSG00000001403
UniProt O00762 Q9D1C1
RefSeq (mRNA) NM_001281741 NM_026785
RefSeq (protein) NP_001268670 NP_081061
Location (UCSC) Chr 20:
44.44 – 44.45 Mb
Chr 2:
164.77 – 164.78 Mb
PubMed search [1] [2]

Ubiquitin-conjugating enzyme E2 C is a protein that in humans is encoded by the UBE2C gene.[1][2]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for the destruction of mitotic cyclins and for cell cycle progression. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined.[2]

References[edit]

  1. ^ Townsley FM, Aristarkhov A, Beck S, Hershko A, Ruderman JV (Apr 1997). "Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase". Proc Natl Acad Sci U S A 94 (6): 2362–7. doi:10.1073/pnas.94.6.2362. PMC 20093. PMID 9122200. 
  2. ^ a b "Entrez Gene: UBE2C ubiquitin-conjugating enzyme E2C". 

Further reading[edit]