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Ubiquitin-conjugating enzyme E2E 1
Protein UBE2E1 PDB 1y6l.png
PDB rendering based on 1y6l.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols UBE2E1 ; UBCH6
External IDs OMIM602916 MGI107411 HomoloGene84372 GeneCards: UBE2E1 Gene
EC number
RNA expression pattern
PBB GE UBE2E1 212519 at tn.png
More reference expression data
Species Human Mouse
Entrez 7324 22194
Ensembl ENSG00000170142 ENSMUSG00000021774
UniProt P51965 P52482
RefSeq (mRNA) NM_001202476 NM_009455
RefSeq (protein) NP_001189405 NP_033481
Location (UCSC) Chr 3:
23.85 – 23.93 Mb
Chr 14:
18.28 – 18.33 Mb
PubMed search [1] [2]

Ubiquitin-conjugating enzyme E2 E1 is a protein that in humans is encoded by the UBE2E1 gene.[1][2]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[2]


UBE2E1 has been shown to interact with Ataxin 1[3] and NEDD4.[4][5]


  1. ^ Nuber U, Schwarz S, Kaiser P, Schneider R, Scheffner M (Mar 1996). "Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7 (E2-F1) and characterization of their interaction with E6-AP and RSP5". J Biol Chem 271 (5): 2795–800. doi:10.1074/jbc.271.5.2795. PMID 8576257. 
  2. ^ a b "Entrez Gene: UBE2E1 ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast)". 
  3. ^ Hong, Sunghoi; Lee Soyeon; Cho Ssang-Goo; Kang Seongman (Jun 2008). "UbcH6 interacts with and ubiquitinates the SCA1 gene product ataxin-1". Biochem. Biophys. Res. Commun. (United States) 371 (2): 256–60. doi:10.1016/j.bbrc.2008.04.066. PMID 18439907. 
  4. ^ Anan, T; Nagata Y, Koga H, Honda Y, Yabuki N, Miyamoto C, Kuwano A, Matsuda I, Endo F, Saya H, Nakao M (Nov 1998). "Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes". Genes Cells (ENGLAND) 3 (11): 751–63. doi:10.1046/j.1365-2443.1998.00227.x. ISSN 1356-9597. PMID 9990509. 
  5. ^ Malakhova, Oxana A; Zhang Dong-Er (Apr 2008). "ISG15 Inhibits Nedd4 Ubiquitin E3 Activity and Enhances the Innate Antiviral Response". J. Biol. Chem. (United States) 283 (14): 8783–7. doi:10.1074/jbc.C800030200. ISSN 0021-9258. PMC 2276364. PMID 18287095. 

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