UBE2G1

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Ubiquitin-conjugating enzyme E2G 1
Protein UBE2G1 PDB 2awf.png
PDB rendering based on 2awf.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols UBE2G1 ; E217K; UBC7; UBE2G
External IDs OMIM601569 MGI1914378 HomoloGene2508 GeneCards: UBE2G1 Gene
EC number 6.3.2.19
RNA expression pattern
PBB GE UBE2G1 209141 at tn.png
PBB GE UBE2G1 209142 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7326 67128
Ensembl ENSG00000132388 ENSMUSG00000020794
UniProt P62253 P62254
RefSeq (mRNA) NM_003342 NM_025985
RefSeq (protein) NP_003333 NP_080261
Location (UCSC) Chr 17:
4.17 – 4.27 Mb
Chr 11:
72.61 – 72.69 Mb
PubMed search [1] [2]

Ubiquitin-conjugating enzyme E2 G1 is a protein that in humans is encoded by the UBE2G1 gene.[1][2]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family and catalyzes the covalent attachment of ubiquitin to other proteins. The protein may be involved in degradation of muscle-specific proteins.[2]

References[edit]

  1. ^ Watanabe TK, Kawai A, Fujiwara T, Maekawa H, Hirai Y, Nakamura Y, Takahashi E (Dec 1996). "Molecular cloning of UBE2G, encoding a human skeletal muscle-specific ubiquitin-conjugating enzyme homologous to UBC7 of C. elegans". Cytogenet Cell Genet 74 (1–2): 146–8. doi:10.1159/000134403. PMID 8893823. 
  2. ^ a b "Entrez Gene: UBE2G1 ubiquitin-conjugating enzyme E2G 1 (UBC7 homolog, yeast)". 

Further reading[edit]