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Ubiquitin-conjugating enzyme E2G 2
Protein UBE2G2 PDB 2cyx.png
PDB rendering based on 2cyx.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols UBE2G2 ; UBC7
External IDs OMIM603124 MGI1343188 HomoloGene6599 GeneCards: UBE2G2 Gene
EC number
RNA expression pattern
PBB GE UBE2G2 209042 s at tn.png
PBB GE UBE2G2 209041 s at tn.png
More reference expression data
Species Human Mouse
Entrez 7327 22213
Ensembl ENSG00000184787 ENSMUSG00000009293
UniProt P60604 P60605
RefSeq (mRNA) NM_001202489 NM_019803
RefSeq (protein) NP_001189418 NP_062777
Location (UCSC) Chr 21:
46.19 – 46.22 Mb
Chr 10:
77.62 – 77.65 Mb
PubMed search [1] [2]

Ubiquitin-conjugating enzyme E2 G2 is a protein that in humans is encoded by the UBE2G2 gene.[1][2][3]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein shares 100% sequence identity with the mouse counterpart. This gene is ubiquitously expressed, with high expression seen in adult muscle. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[3] Ube2g2 is known to interact with a variety of other proteins, including but not limited to ubiquitin, the E3 gp78, and the Hrd1 RING.


  1. ^ Katsanis N, Fisher EM (Sep 1998). "Identification, expression, and chromosomal localization of ubiquitin conjugating enzyme 7 (UBE2G2), a human homologue of the Saccharomyces cerevisiae ubc7 gene". Genomics 51 (1): 128–31. doi:10.1006/geno.1998.5263. PMID 9693041. 
  2. ^ Rose SA, Leek JP, Moynihan TP, Ardley HC, Markham AF, Robinson PA (Mar 1999). "Assignment1 of the ubiquitin conjugating enzyme gene, UBE2G2, to human chromosome band 21q22.3 by in situ hybridization". Cytogenet Cell Genet 83 (1–2): 98–9. doi:10.1159/000015141. PMID 9925943. 
  3. ^ a b "Entrez Gene: UBE2G2 ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast)". 

Further reading[edit]