UBE2H

Ubiquitin-conjugating enzyme E2H
PDB rendering based on 1yh6.
Available structures PDB 1yh6
Identifiers
Symbols	UBE2H; E2-20K; UBC8; UBCH; UBCH2
External IDs	OMIM: 601082 MGI: 104632 HomoloGene: 103894 GeneCards: UBE2H Gene
EC number	6.3.2.19
Gene Ontology Molecular function • nucleotide binding • ubiquitin-protein ligase activity • ATP binding • ligase activity • acid-amino acid ligase activity Biological process • ubiquitin-dependent protein catabolic process • protein ubiquitination • protein K48-linked ubiquitination • protein K11-linked ubiquitination Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	7328	22214
Ensembl	ENSG00000186591	ENSMUSG00000039159
UniProt	P62256	Q3V2N4
RefSeq (mRNA)	NM_001202498.1	XM_989140
RefSeq (protein)	NP_001189427.1	XP_994234
Location (UCSC)	Chr 7: 129.47 – 129.59 Mb	Chr 6: 30.16 – 30.25 Mb
PubMed search	[1]	[2]

Ubiquitin-conjugating enzyme E2 H is a protein that in humans is encoded by the UBE2H gene.

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.

Further reading

• Wefes I, Mastrandrea LD, Haldeman M, et al. (1995). "Induction of ubiquitin-conjugating enzymes during terminal erythroid differentiation.". Proc. Natl. Acad. Sci. U.S.A. 92 (11): 4982–6. doi:10.1073/pnas.92.11.4982. PMC 41831. PMID 7761435. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=41831. 
• Kaiser P, Mandl S, Schweiger M, Schneider R (1996). "Characterization of functionally independent domains in the human ubiquitin conjugating enzyme UbcH2.". FEBS Lett. 377 (2): 193–6. doi:10.1016/0014-5793(95)01323-7. PMID 8543049. 
• Hayashida S, Yamasaki K, Asada Y, et al. (2000). "Construction of a physical and transcript map flanking the imprinted MEST/PEG1 region at 7q32.". Genomics 66 (2): 221–5. doi:10.1006/geno.2000.6206. PMID 10860668. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology.". Science 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2882961. 
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7.". Nature 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948. 
• Vourc'h P, Martin I, Bonnet-Brilhault F, et al. (2005). "Mutation screening and association study of the UBE2H gene on chromosome 7q32 in autistic disorder.". Psychiatr. Genet. 13 (4): 221–5. doi:10.1097/01.ypg.0000084946.07075.37. PMID 14639049. 
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Bartee E, Mansouri M, Hovey Nerenberg BT, et al. (2004). "Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins.". J. Virol. 78 (3): 1109–20. doi:10.1128/JVI.78.3.1109-1120.2004. PMC 321412. PMID 14722266. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=321412. 
• Chuang TH, Ulevitch RJ (2004). "Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors.". Nat. Immunol. 5 (5): 495–502. doi:10.1038/ni1066. PMID 15107846. 
• Kim HJ, Chong KH, Kang SW, et al. (2005). "Identification of cyclophilin A as a CD99-binding protein by yeast two-hybrid screening.". Immunol. Lett. 95 (2): 155–9. doi:10.1016/j.imlet.2004.07.001. PMID 15388255. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.