UBE2J1

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Ubiquitin-conjugating enzyme E2, J1
Identifiers
Symbols UBE2J1 ; HSPC153; HSPC205; HSU93243; NCUBE-1; NCUBE1; UBC6; Ubc6p
External IDs MGI1926245 HomoloGene41090 GeneCards: UBE2J1 Gene
EC number 6.3.2.19
RNA expression pattern
PBB GE UBE2J1 217823 s at tn.png
PBB GE UBE2J1 217824 at tn.png
PBB GE UBE2J1 217825 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 51465 56228
Ensembl ENSG00000198833 ENSMUSG00000028277
UniProt Q9Y385 Q9JJZ4
RefSeq (mRNA) NM_016021 NM_019586
RefSeq (protein) NP_057105 NP_062532
Location (UCSC) Chr 6:
90.04 – 90.06 Mb
Chr 4:
33.03 – 33.05 Mb
PubMed search [1] [2]

Ubiquitin-conjugating enzyme E2 J1 is a protein that in humans is encoded by the UBE2J1 gene.[1][2]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is located in the membrane of the endoplasmic reticulum (ER) and may contribute to quality control ER-associated degradation by the ubiquitin-proteasome system.[2]

References[edit]

  1. ^ Lester D, Farquharson C, Russell G, Houston B (Apr 2000). "Identification of a family of noncanonical ubiquitin-conjugating enzymes structurally related to yeast UBC6". Biochem Biophys Res Commun 269 (2): 474–80. doi:10.1006/bbrc.2000.2302. PMID 10708578. 
  2. ^ a b "Entrez Gene: UBE2J1 ubiquitin-conjugating enzyme E2, J1 (UBC6 homolog, yeast)". 

Further reading[edit]