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Ubiquitin-conjugating enzyme E2L 3
Protein UBE2L3 PDB 1c4z.png
PDB rendering based on 1c4z.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols UBE2L3 ; E2-F1; L-UBC; UBCH7; UbcM4
External IDs OMIM603721 MGI109240 HomoloGene43226 GeneCards: UBE2L3 Gene
EC number
RNA expression pattern
PBB GE UBE2L3 200682 s at tn.png
PBB GE UBE2L3 200676 s at tn.png
PBB GE UBE2L3 200683 s at tn.png
More reference expression data
Species Human Mouse
Entrez 7332 22195
Ensembl ENSG00000185651 ENSMUSG00000038965
UniProt P68036 P68037
RefSeq (mRNA) NM_001256355 NM_009456
RefSeq (protein) NP_001243284 NP_033482
Location (UCSC) Chr 22:
21.9 – 21.98 Mb
Chr 16:
17.15 – 17.2 Mb
PubMed search [1] [2]

Ubiquitin-conjugating enzyme E2 L3 is a protein that in humans is encoded by the UBE2L3 gene.[1][2][3]


The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-κB precursor p105 in vitro. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[3]


UBE2L3 has been shown to interact with:


  1. ^ Moynihan T, Ardley H, Leek J, Thompson J, Brindle N, Markham A et al. (October 1996). "Characterization of a human ubiquitin-conjugating enzyme gene UBE2L3". Mamm. Genome 7 (7): 520–5. doi:10.1007/s003359900155. PMID 8672131. 
  2. ^ Moynihan T, Cole C, Dunham I, O'Neil L, Markham A, Robinson P (September 1998). "Fine-mapping, genomic organization, and transcript analysis of the human ubiquitin-conjugating enzyme gene UBE2L3". Genomics 51 (1): 124–7. doi:10.1006/geno.1998.5257. PMID 9693040. 
  3. ^ a b "Entrez Gene: UBE2L3 ubiquitin-conjugating enzyme E2L 3". 
  4. ^ Tan N, Ardley H, Scott G, Rose S, Markham A, Robinson P (November 2003). "Human homologue of ariadne promotes the ubiquitylation of translation initiation factor 4E homologous protein, 4EHP". FEBS Lett. 554 (3): 501–4. PMID 14623119. 
  5. ^ Moynihan T, Ardley H, Nuber U, Rose S, Jones P, Markham A et al. (October 1999). "The ubiquitin-conjugating enzymes UbcH7 and UbcH8 interact with RING finger/IBR motif-containing domains of HHARI and H7-AP1". J. Biol. Chem. 274 (43): 30963–8. PMID 10521492. 
  6. ^ Ardley H, Tan N, Rose S, Markham A, Robinson P (June 2001). "Features of the parkin/ariadne-like ubiquitin ligase, HHARI, that regulate its interaction with the ubiquitin-conjugating enzyme, Ubch7". J. Biol. Chem. 276 (22): 19640–7. doi:10.1074/jbc.M011028200. PMID 11278816. 
  7. ^ Yokouchi M, Kondo T, Houghton A, Bartkiewicz M, Horne W, Zhang H et al. (October 1999). "Ligand-induced ubiquitination of the epidermal growth factor receptor involves the interaction of the c-Cbl RING finger and UbcH7". J. Biol. Chem. 274 (44): 31707–12. PMID 10531381. 
  8. ^ Zheng N, Wang P, Jeffrey P, Pavletich N (August 2000). "Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases". Cell 102 (4): 533–9. PMID 10966114. 
  9. ^ Wong E, Fong C, Lim J, Yusoff P, Low B, Langdon W et al. (September 2002). "Sprouty2 attenuates epidermal growth factor receptor ubiquitylation and endocytosis, and consequently enhances Ras/ERK signalling". EMBO J. 21 (18): 4796–808. PMC 126289. PMID 12234920. 
  10. ^ a b Anan T, Nagata Y, Koga H, Honda Y, Yabuki N, Miyamoto C et al. (November 1998). "Human ubiquitin-protein ligase Nedd4: expression, subcellular localization and selective interaction with ubiquitin-conjugating enzymes". Genes Cells 3 (11): 751–63. PMID 9990509. 
  11. ^ Bruce M, Kanelis V, Fouladkou F, Debonneville A, Staub O, Rotin D (October 2008). "Regulation of Nedd4-2 self-ubiquitination and stability by a PY motif located within its HECT-domain". Biochem. J. 415 (1): 155–63. doi:10.1042/BJ20071708. PMID 18498246. 
  12. ^ Nuber U, Schwarz S, Kaiser P, Schneider R, Scheffner M (February 1996). "Cloning of human ubiquitin-conjugating enzymes UbcH6 and UbcH7 (E2-F1) and characterization of their interaction with E6-AP and RSP5". J. Biol. Chem. 271 (5): 2795–800. PMID 8576257. 
  13. ^ Huang L, Kinnucan E, Wang G, Beaudenon S, Howley P, Huibregtse J et al. (November 1999). "Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade". Science 286 (5443): 1321–6. PMID 10558980. 
  14. ^ Pringa E, Martinez-Noel G, Muller U, Harbers K (June 2001). "Interaction of the ring finger-related U-box motif of a nuclear dot protein with ubiquitin-conjugating enzymes". J. Biol. Chem. 276 (22): 19617–23. doi:10.1074/jbc.M100192200. PMID 11274149. 

Further reading[edit]