UBE2R2

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Ubiquitin-conjugating enzyme E2R 2
Identifiers
Symbols UBE2R2 ; CDC34B; E2-CDC34B; UBC3B
External IDs OMIM612506 MGI1914865 HomoloGene3210 GeneCards: UBE2R2 Gene
EC number 6.3.2.19
RNA expression pattern
PBB GE UBE2R2 gnf1h00269 at tn.png
PBB GE UBE2R2 gnf1h07191 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 54926 67615
Ensembl ENSG00000107341 ENSMUSG00000036241
UniProt Q712K3 Q6ZWZ2
RefSeq (mRNA) NM_017811 NM_026275
RefSeq (protein) NP_060281 NP_080551
Location (UCSC) Chr 9:
33.82 – 33.92 Mb
Chr 4:
41.14 – 41.19 Mb
PubMed search [1] [2]

Ubiquitin-conjugating enzyme E2 R2 is a protein that in humans is encoded by the UBE2R2 gene.[1][2]

Protein kinase CK2 is a ubiquitous and pleiotropic Ser/Thr protein kinase involved in cell growth and transformation. This gene encodes a protein similar to the E2 ubiquitin conjugating enzyme UBC3/CDC34. Studies suggest that CK2-dependent phosphorylation of this ubiquitin-conjugating enzyme functions by regulating beta-TrCP substrate recognition and induces its interaction with beta-TrCP, enhancing beta-catenin degradation.[2]

References[edit]

  1. ^ Semplici F, Meggio F, Pinna LA, Oliviero S (May 2002). "CK2-dependent phosphorylation of the E2 ubiquitin conjugating enzyme UBC3B induces its interaction with beta-TrCP and enhances beta-catenin degradation". Oncogene 21 (25): 3978–87. doi:10.1038/sj.onc.1205574. PMID 12037680. 
  2. ^ a b "Entrez Gene: UBE2R2 ubiquitin-conjugating enzyme E2R 2". 

Further reading[edit]