UBE2V2

Ubiquitin-conjugating enzyme E2 variant 2
	; PDB rendering based on 1j74.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1J74, 1J7D, 1ZGU
Identifiers
Symbols	UBE2V2; DDVIT1; DDVit-1; EDAF-1; EDPF-1; EDPF1; MMS2; UEV-2; UEV2
External IDs	OMIM: 603001 MGI: 1917870 HomoloGene: 55739 GeneCards: UBE2V2 Gene
Gene Ontology
Molecular function	• protein binding; • acid-amino acid ligase activity;
Cellular component	• nucleus; • cytoplasm; • UBC13-MMS2 complex;
Biological process	• protein polyubiquitination; • DNA double-strand break processing; • regulation of DNA repair; • cell proliferation; • protein ubiquitination;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs

Ubiquitin-conjugating enzyme E2 variant 2 is a protein that in humans is encoded by the UBE2V2 gene.^[1]^[2]^[3]

Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene also shares homology with ubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2 gene product. It may be involved in the differentiation of monocytes and enterocytes.^[3]

[edit] Interactions

UBE2V2 has been shown to interact with HLTF.^[4]

[edit] References

^ Sancho E, Vila MR, Sanchez-Pulido L, Lozano JJ, Paciucci R, Nadal M, Fox M, Harvey C, Bercovich B, Loukili N, Ciechanover A, Lin SL, Sanz F, Estivill X, Valencia A, Thomson TM (Jan 1998). "Role of UEV-1, an Inactive Variant of the E2 UbiquitinConjugating Enzymes, in In Vitro Differentiation and Cell Cycle Behavior of HT-29-M6 Intestinal Mucosecretory Cells". Mol Cell Biol 18 (1): 576–89. PMC 121525. PMID 9418904. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=121525.
^ Fritsche J, Rehli M, Krause SW, Andreesen R, Kreutz M (Jul 1997). "Molecular cloning of a 1alpha,25-dihydroxyvitamin D3-inducible transcript (DDVit 1) in human blood monocytes". Biochem Biophys Res Commun 235 (2): 407–12. doi:10.1006/bbrc.1997.6798. PMID 9199207.
^ ^a ^b "Entrez Gene: UBE2V2 ubiquitin-conjugating enzyme E2 variant 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7336.
^ Unk, Ildiko; Hajdú Ildikó, Fátyol Károly, Hurwitz Jerard, Yoon Jung-Hoon, Prakash Louise, Prakash Satya, Haracska Lajos (Mar. 2008). "Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination". Proc. Natl. Acad. Sci. U.S.A. (United States) 105 (10): 3768–73. doi:10.1073/pnas.0800563105. PMC 2268824. PMID 18316726. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2268824.

[edit] Further reading

Xiao W, Lin SL, Broomfield S et al (1998). "The products of the yeast MMS2 and two human homologs (hMMS2 and CROC-1) define a structurally and functionally conserved Ubc-like protein family". Nucleic Acids Res. 26 (17): 3908–14. doi:10.1093/nar/26.17.3908. PMC 147796. PMID 9705497. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=147796.
Hofmann RM, Pickart CM (1999). "Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair". Cell 96 (5): 645–53. doi:10.1016/S0092-8674(00)80575-9. PMID 10089880.
Chan NL, Hill CP (2001). "Defining polyubiquitin chain topology". Nat. Struct. Biol. 8 (8): 650–2. doi:10.1038/90337. PMID 11473244.
Moraes TF, Edwards RA, McKenna S et al (2001). "Crystal structure of the human ubiquitin conjugating enzyme complex, hMms2-hUbc13". Nat. Struct. Biol. 8 (8): 669–73. doi:10.1038/90373. PMID 11473255.
Strausberg RL, Feingold EA, Grouse LH et al (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241.
Gevaert K, Goethals M, Martens L et al (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801.
Bothos J, Summers MK, Venere M et al (2003). "The Chfr mitotic checkpoint protein functions with Ubc13-Mms2 to form Lys63-linked polyubiquitin chains". Oncogene 22 (46): 7101–7. doi:10.1038/sj.onc.1206831. PMID 14562038.
Zhou H, Wertz I, O'Rourke K et al (2004). "Bcl10 activates the NF-kappaB pathway through ubiquitination of NEMO". Nature 427 (6970): 167–71. doi:10.1038/nature02273. PMID 14695475.
Ota T, Suzuki Y, Nishikawa T et al (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Gerhard DS, Wagner L, Feingold EA et al (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928.
Simpson LJ, Sale JE (2005). "UBE2V2 (MMS2) is not required for effective immunoglobulin gene conversion or DNA damage tolerance in DT40". DNA Repair (Amst.) 4 (4): 503–10. doi:10.1016/j.dnarep.2004.12.002. PMID 15725630.
Pastushok L, Moraes TF, Ellison MJ, Xiao W (2005). "A single Mms2 "key" residue insertion into a Ubc13 pocket determines the interface specificity of a human Lys63 ubiquitin conjugation complex". J. Biol. Chem. 280 (18): 17891–900. doi:10.1074/jbc.M410469200. PMID 15749714.
Spyracopoulos L, Lewis MJ, Saltibus LF (2005). "Main chain and side chain dynamics of the ubiquitin conjugating enzyme variant human Mms2 in the free and ubiquitin-bound States". Biochemistry 44 (24): 8770–81. doi:10.1021/bi050065k. PMID 15952783.
Andersen PL, Zhou H, Pastushok L et al (2005). "Distinct regulation of Ubc13 functions by the two ubiquitin-conjugating enzyme variants Mms2 and Uev1A". J. Cell Biol. 170 (5): 745–55. doi:10.1083/jcb.200502113. PMC 2171356. PMID 16129784. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2171356.
Stelzl U, Worm U, Lalowski M et al (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Wen R, Newton L, Li G et al (2006). "Arabidopsis thaliana UBC13: implication of error-free DNA damage tolerance and Lys63-linked polyubiquitylation in plants". Plant Mol. Biol. 61 (1–2): 241–53. doi:10.1007/s11103-006-0007-x. PMID 16786304.
Zhao GY, Sonoda E, Barber LJ et al (2007). "A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination". Mol. Cell 25 (5): 663–75. doi:10.1016/j.molcel.2007.01.029. PMID 17349954.