From Wikipedia, the free encyclopedia
Jump to: navigation, search
Ubiquitin-conjugating enzyme E2 variant 2
Protein UBE2V2 PDB 1j74.png
PDB rendering based on 1j74.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols UBE2V2 ; DDVIT1; DDVit-1; EDAF-1; EDPF-1; EDPF1; MMS2; UEV-2; UEV2
External IDs OMIM603001 MGI1917870 HomoloGene55739 ChEMBL: 5235 GeneCards: UBE2V2 Gene
RNA expression pattern
PBB GE UBE2V2 209096 at tn.png
More reference expression data
Species Human Mouse
Entrez 7336 70620
Ensembl ENSG00000169139 ENSMUSG00000022674
UniProt Q15819 Q9D2M8
RefSeq (mRNA) NM_003350 NM_001159351
RefSeq (protein) NP_003341 NP_001152823
Location (UCSC) Chr 20:
48.7 – 48.73 Mb
Chr 16:
15.55 – 15.59 Mb
PubMed search [1] [2]

Ubiquitin-conjugating enzyme E2 variant 2 is a protein that in humans is encoded by the UBE2V2 gene.[1][2][3]

Ubiquitin-conjugating enzyme E2 variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene also shares homology with ubiquitin-conjugating enzyme E2 variant 1 and yeast MMS2 gene product. It may be involved in the differentiation of monocytes and enterocytes.[3]


UBE2V2 has been shown to interact with HLTF.[4]


  1. ^ Sancho E, Vila MR, Sanchez-Pulido L, Lozano JJ, Paciucci R, Nadal M, Fox M, Harvey C, Bercovich B, Loukili N, Ciechanover A, Lin SL, Sanz F, Estivill X, Valencia A, Thomson TM (Jan 1998). "Role of UEV-1, an Inactive Variant of the E2 UbiquitinConjugating Enzymes, in In Vitro Differentiation and Cell Cycle Behavior of HT-29-M6 Intestinal Mucosecretory Cells". Mol Cell Biol 18 (1): 576–89. PMC 121525. PMID 9418904. 
  2. ^ Fritsche J, Rehli M, Krause SW, Andreesen R, Kreutz M (Jul 1997). "Molecular cloning of a 1alpha,25-dihydroxyvitamin D3-inducible transcript (DDVit 1) in human blood monocytes". Biochem Biophys Res Commun 235 (2): 407–12. doi:10.1006/bbrc.1997.6798. PMID 9199207. 
  3. ^ a b "Entrez Gene: UBE2V2 ubiquitin-conjugating enzyme E2 variant 2". 
  4. ^ Unk, Ildiko; Hajdú Ildikó; Fátyol Károly; Hurwitz Jerard; Yoon Jung-Hoon; Prakash Louise; Prakash Satya; Haracska Lajos (Mar 2008). "Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination". Proc. Natl. Acad. Sci. U.S.A. (United States) 105 (10): 3768–73. doi:10.1073/pnas.0800563105. PMC 2268824. PMID 18316726. 

Further reading[edit]