UBE4A

Ubiquitination factor E4A
PDB rendering based on 1wgm.
Available structures PDB 1wgm
Identifiers
Symbols	UBE4A; E4; KIAA0126; MGC133315; UBOX2; UFD2
External IDs	OMIM: 603753 MGI: 2154580 HomoloGene: 3517 GeneCards: UBE4A Gene
Gene Ontology Molecular function • protein binding • ubiquitin-ubiquitin ligase activity Cellular component • ubiquitin ligase complex • cytoplasm Biological process • protein polyubiquitination • ubiquitin-dependent protein catabolic process Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9354	140630
Ensembl	ENSG00000110344	ENSMUSG00000059890
UniProt	Q14139	n/a
RefSeq (mRNA)	NM_001204077.1	NM_145400.3
RefSeq (protein)	NP_001191006.1	NP_663375.3
Location (UCSC)	Chr 11: 118.23 – 118.74 Mb	Chr 9: 44.73 – 44.77 Mb
PubMed search	[1]	[2]

Ubiquitin conjugation factor E4 A is a protein that in humans is encoded by the UBE4A gene.

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly.

Further reading

• Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, et al. (1995). "Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening.". Genomics 23 (1): 42–50. doi:10.1006/geno.1994.1457. PMID 7829101. 
• Nagase T, Seki N, Tanaka A, et al. (1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1.". DNA Res. 2 (4): 167–74, 199–210. doi:10.1093/dnares/2.4.167. PMID 8590280. 
• Mahoney JA, Odin JA, White SM, et al. (2002). "The human homologue of the yeast polyubiquitination factor Ufd2p is cleaved by caspase 6 and granzyme B during apoptosis.". Biochem. J. 361 (Pt 3): 587–95. doi:10.1042/0264-6021:3610587. PMC 1222341. PMID 11802788. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1222341. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. 
• Contino G, Amati F, Pucci S, et al. (2004). "Expression analysis of the gene encoding for the U-box-type ubiquitin ligase UBE4A in human tissues.". Gene 328: 69–74. doi:10.1016/j.gene.2003.11.017. PMID 15019985. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Spinette S, Lengauer C, Mahoney JA, et al. (2006). "Ufd2, a novel autoantigen in scleroderma, regulates sister chromatid separation.". Cell Cycle 3 (12): 1638–44. PMID 15611659. 
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1847948.