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Ubiquitin protein ligase E3 component n-recognin 5
PBB Protein EDD1 image.jpg
PDB rendering based on 1i2t.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols UBR5 ; DD5; EDD; EDD1; HYD
External IDs OMIM608413 MGI1918040 HomoloGene9295 GeneCards: UBR5 Gene
Species Human Mouse
Entrez 51366 70790
Ensembl ENSG00000104517 ENSMUSG00000037487
UniProt O95071 Q80TP3
RefSeq (mRNA) NM_001282873 NM_001081359
RefSeq (protein) NP_001269802 NP_001074828
Location (UCSC) Chr 8:
103.27 – 103.43 Mb
Chr 15:
37.97 – 38.08 Mb
PubMed search [1] [2]

E3 ubiquitin-protein ligase UBR5 is an enzyme that in humans is encoded by the UBR5 gene.[1][2][3]


This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation.[3]


UBR5 has been shown to interact with:


  1. ^ Callaghan MJ, Russell AJ, Woollatt E, Sutherland GR, Sutherland RL, Watts CK (Mar 1999). "Identification of a human HECT family protein with homology to the Drosophila tumor suppressor gene hyperplastic discs". Oncogene 17 (26): 3479–91. doi:10.1038/sj.onc.1202249. PMID 10030672. 
  2. ^ Tasaki T, Mulder LC, Iwamatsu A, Lee MJ, Davydov IV, Varshavsky A et al. (Aug 2005). "A Family of Mammalian E3 Ubiquitin Ligases That Contain the UBR Box Motif and Recognize N-Degrons". Mol Cell Biol 25 (16): 7120–36. doi:10.1128/MCB.25.16.7120-7136.2005. PMC 1190250. PMID 16055722. 
  3. ^ a b "Entrez Gene: EDD1 E3 ubiquitin protein ligase, HECT domain containing, 1". 
  4. ^ a b Henderson MJ, Russell AJ, Hird S, Muñoz M, Clancy JL, Lehrbach GM et al. (Jul 2002). "EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response". J. Biol. Chem. 277 (29): 26468–78. doi:10.1074/jbc.M203527200. PMID 12011095. 
  5. ^ Eblen ST, Kumar NV, Shah K, Henderson MJ, Watts CK, Shokat KM et al. (Apr 2003). "Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs". J. Biol. Chem. 278 (17): 14926–35. doi:10.1074/jbc.M300485200. PMID 12594221. 
  6. ^ Honda Y, Tojo M, Matsuzaki K, Anan T, Matsumoto M, Ando M et al. (Feb 2002). "Cooperation of HECT-domain ubiquitin ligase hHYD and DNA topoisomerase II-binding protein for DNA damage response". J. Biol. Chem. 277 (5): 3599–605. doi:10.1074/jbc.M104347200. PMID 11714696. 

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