UDP-glucuronate 5'-epimerase

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UDP-glucuronate 5'-epimerase
Identifiers
EC number 5.1.3.12
CAS number 37318-38-0
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, an UDP-glucuronate 5'-epimerase (EC 5.1.3.12) is an enzyme that catalyzes the chemical reaction

UDP-glucuronate \rightleftharpoons UDP-L-iduronate

Hence, this enzyme has one substrate, UDP-glucuronate, and one product, UDP-L-iduronate.

This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on carbohydrates and derivatives. The systematic name of this enzyme class is UDP-glucuronate 5'-epimerase. Other names in common use include uridine diphosphoglucuronate 5'-epimerase, UDP-glucuronic acid 5'-epimerase, and C-5-uronosyl epimerase. This enzyme participates in nucleotide sugars metabolism. It employs one cofactor, NAD+.

References[edit]

  • Jacobson B and Davidson EA (1962). "Biosynthesis of uronic acids by skin enzymes. I. Uridine diphosphate-D-glucuronic acid-5-epimerase". J. Biol. Chem. 237: 638–642. PMID 14450717.