The event was headlined by a Light Heavyweight Championship bout between Frank Shamrock and Tito Ortiz. The Ortiz-Shamrock fight was notable for being widely considered one of the best MMA fights ever at the time it took place, due to the complete range of skills shown by both fighters. The bout featured back-and-forth action which saw multiple takedowns from Ortiz and crisp kickboxing displayed by Shamrock, who eventually forced Ortiz into submission with brutal punches, elbows, and hammerfists to the temple late in the 4th round. Shamrock would begin his short lived semi-retirement after this bout, citing a lack of competition.
UFC 22 marked the first UFC appearance of future UFC Welterweight Champion Matt Hughes, who would go on to dominate the UFC's Welterweight division, as well as Jens Pulver, who fought in a preliminary bout that was not televised.