UGT1A5

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UDP glucuronosyltransferase 1 family, polypeptide A5
Identifiers
Symbols UGT1A5 ; UDPGT; UDPGT 1-5; UGT1E
External IDs OMIM606430 HomoloGene117984 GeneCards: UGT1A5 Gene
EC number 2.4.1.17
Orthologs
Species Human Mouse
Entrez 54579 n/a
Ensembl ENSG00000240224 n/a
UniProt P35504 n/a
RefSeq (mRNA) NM_019078 n/a
RefSeq (protein) NP_061951 n/a
Location (UCSC) Chr 2:
234.62 – 234.68 Mb
n/a
PubMed search [1] n/a

UDP-glucuronosyltransferase 1-5 is an enzyme that in humans is encoded by the UGT1A5 gene.[1][2][3]

Function[edit]

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter.[1]

References[edit]

  1. ^ a b "Entrez Gene: UDP glucuronosyltransferase 1 family". 
  2. ^ Ritter JK, Chen F, Sheen YY, Tran HM, Kimura S, Yeatman MT, Owens IS (February 1992). "A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini". J. Biol. Chem. 267 (5): 3257–61. PMID 1339448. 
  3. ^ Mackenzie PI, Owens IS, Burchell B, Bock KW, Bairoch A, Bélanger A, Fournel-Gigleux S, Green M, Hum DW, Iyanagi T, Lancet D, Louisot P, Magdalou J, Chowdhury JR, Ritter JK, Schachter H, Tephly TR, Tipton KF, Nebert DW (August 1997). "The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence". Pharmacogenetics 7 (4): 255–69. doi:10.1097/00008571-199708000-00001. PMID 9295054. 

Further reading[edit]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.