UGT1A7 (gene)

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UDP glucuronosyltransferase 1 family, polypeptide A7
Identifiers
Symbols UGT1A7 ; UDPGT; UDPGT 1-7; UGT-1G; UGT1-07; UGT1.7; UGT1G
External IDs OMIM606432 HomoloGene133281 ChEMBL: 1743317 GeneCards: UGT1A7 Gene
EC number 2.4.1.17
Orthologs
Species Human Mouse
Entrez 54577 394430
Ensembl ENSG00000244122 ENSMUSG00000090165
UniProt Q9HAW7 Q5FW80
RefSeq (mRNA) NM_019077 NM_201641
RefSeq (protein) NP_061950 NP_964003
Location (UCSC) Chr 2:
234.59 – 234.68 Mb
Chr 1:
88.06 – 88.22 Mb
PubMed search [1] [2]

UDP glucuronosyltransferase 1 family, polypeptide A7 is a protein that in humans is encoded by the UGT1A7 gene.[1]

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has moderate glucuronidase activity with phenols. [provided by RefSeq, Jul 2008].[1]

References[edit]

Further reading[edit]

  • Tukey, R. H.; Strassburg, C. P. (2000). "Human UDP-Glucuronosyltransferases: Metabolism, Expression, and Disease". Annual Review of Pharmacology and Toxicology 40: 581–616. doi:10.1146/annurev.pharmtox.40.1.581. PMID 10836148.  edit
  • Guillemette, C.; Ritter, J. K.; Auyeung, D. J.; Kessler, F. K.; Housman, D. E. (2000). "Structural heterogeneity at the UDP-glucuronosyltransferase 1 locus: Functional consequences of three novel missense mutations in the human UGT1A7 gene". Pharmacogenetics 10 (7): 629–644. doi:10.1097/00008571-200010000-00006. PMID 11037804.  edit
  • Gong, Q. H.; Cho, J. W.; Huang, T.; Potter, C.; Gholami, N.; Basu, N. K.; Kubota, S.; Carvalho, S.; Pennington, M. W.; Owens, I. S.; Popescu, N. C. (2001). "Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus". Pharmacogenetics 11 (4): 357–368. doi:10.1097/00008571-200106000-00011. PMID 11434514.  edit
  • King, C. D.; Rios, G. R.; Green, M. D.; Tephly, T. R. (2000). "UDP-glucuronosyltransferases". Current drug metabolism 1 (2): 143–161. doi:10.2174/1389200003339171. PMID 11465080.  edit
  • Zheng, Z.; Park, J. Y.; Guillemette, C.; Schantz, S. P.; Lazarus, P. (2001). "Tobacco carcinogen-detoxifying enzyme UGT1A7 and its association with orolaryngeal cancer risk". Journal of the National Cancer Institute 93 (18): 1411–1418. doi:10.1093/jnci/93.18.1411. PMID 11562393.  edit
  • Vogel, A.; Kneip, S.; Barut, A.; Ehmer, U.; Tukey, R. H.; Manns, M. P.; Strassburg, C. P. (2001). "Genetic link of hepatocellular carcinoma with polymorphisms of the UDP-glucuronosyltransferase UGT1A7 gene". Gastroenterology 121 (5): 1136–1144. doi:10.1053/gast.2001.28655. PMID 11677206.  edit
  • Strassburg, C. P.; Vogel, A.; Kneip, S.; Tukey, R. H.; Manns, M. P. (2002). "Polymorphisms of the human UDP-glucuronosyltransferase (UGT) 1A7 gene in colorectal cancer". Gut 50 (6): 851–856. doi:10.1136/gut.50.6.851. PMC 1773251. PMID 12010889.  edit
  • Vogel, A.; Ockenga, J.; Ehmer, U.; Barut, A.; Kramer, F. -J.; Tukey, R. H.; Manns, M. P.; Strassburg, C. P. (2002). "Polymorphisms of the Carcinogen Detoxifying UDP-Glucuronosyltransferase UGT1A7 in Proximal Digestive Tract Cancer". Zeitschrift für Gastroenterologie 40 (7): 497–502. doi:10.1055/s-2002-32805. PMID 12122597.  edit
  • Köhle, C.; Möhrle, B.; Münzel, P. A.; Schwab, M.; Wernet, D.; Badary, O. A.; Bock, K. W. (2003). "Frequent co-occurrence of the TATA box mutation associated with Gilbert's syndrome (UGT1A1*28) with other polymorphisms of the UDP-glucuronosyltransferase-1 locus (UGT1A6*2 and UGT1A7*3) in Caucasians and Egyptians". Biochemical pharmacology 65 (9): 1521–1527. doi:10.1016/S0006-2952(03)00074-1. PMID 12732365.  edit
  • Ockenga, J.; Vogel, A.; Teich, N.; Keim, V.; Manns, M. P.; Strassburg, C. P. (2003). "UDP glucuronosyltransferase (UGT1A7) gene polymorphisms increase the risk of chronic pancreatitis and pancreatic cancer". Gastroenterology 124 (7): 1802–1808. doi:10.1016/s0016-5085(03)00294-4. PMID 12806614.  edit