UGT2A2

From Wikipedia, the free encyclopedia
Jump to: navigation, search
UDP glucuronosyltransferase 2 family, polypeptide A2
Identifiers
Symbol UGT2A2
External IDs MGI3576095 HomoloGene115736 GeneCards: UGT2A2 Gene
EC number 2.4.1.17
Orthologs
Species Human Mouse
Entrez 574537 552899
Ensembl ENSG00000173610 ENSMUSG00000029268
UniProt Q9Y4X1 Q6PDD0
RefSeq (mRNA) NM_001105677 NM_001024148
RefSeq (protein) NP_001099147 NP_001019319
Location (UCSC) Chr 4:
70.45 – 70.52 Mb
Chr 5:
87.46 – 87.49 Mb
PubMed search [1] [2]

'UDP glucuronosyltransferase 2 family, polypeptide A2, also known as UGT2A2, is an enzyme that in humans is encoded by the UGT2A2 gene.[1][2]

Function[edit]

The olfactory neuroepithelium, which lines the posterior nasal cavity, is exposed to a wide range of odorants and airborne toxic compounds. Odorants, which are mostly small lipophilic molecules, enter the mucus flow and reach the odorant receptors on sensory neurons. Odorant sensing is generally a transient process, requiring an effective signal termination, which could be provided by biotransformation of the odorant in the epithelial supporting cells. Xenobiotic-metabolizing enzymes in the olfactory epithelium have been suggested to catalyze inactivation and facilitate elimination of odorants.[1]

References[edit]

  1. ^ a b "Entrez Gene: UDP glucuronosyltransferase 2 family, polypeptide A2". 
  2. ^ Mackenzie PI, Bock KW, Burchell B, Guillemette C, Ikushiro S, Iyanagi T, Miners JO, Owens IS, Nebert DW (October 2005). "Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily". Pharmacogenet. Genomics 15 (10): 677–85. doi:10.1097/01.fpc.0000173483.13689.56. PMID 16141793. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.