UGT2B4

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UDP glucuronosyltransferase 2 family, polypeptide B4
Identifiers
Symbols UGT2B4 ; HLUG25; UDPGT2B4; UDPGTH1; UDPGTh-1; UGT2B11
External IDs OMIM600067 HomoloGene130717 ChEMBL: 6196 GeneCards: UGT2B4 Gene
EC number 2.4.1.17
RNA expression pattern
PBB GE UGT2B4 206505 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7363 71773
Ensembl ENSG00000156096 ENSMUSG00000035836
UniProt P06133 Q8R084
RefSeq (mRNA) NM_001297615 NM_152811.1
RefSeq (protein) NP_001284544 NP_690024.1
Location (UCSC) Chr 4:
70.35 – 70.39 Mb
Chr 5:
87.35 – 87.36 Mb
PubMed search [1] [2]

UDP glucuronosyltransferase 2 family, polypeptide B4, also known as UGT2B4, is an enzyme that in humans is encoded by the UGT2B4 gene.[1][2][3]

Function[edit]

UGT2B4 is mainly involved in the glucuronidation of hyodeoxycholic acid, a bile acid, and catechol-estrogens, such as 17-epiestriol and 4-hydroxy-estrone.[4]

The expression of the UGT2B4 enzyme is upregulated by the farnesoid X receptor (FXR), a nuclear receptor which is activated by bile acids.[5] These same bile acids are substrates for the UGT2B4 enzyme. Hence upregulation of UGT2B4 by activated FXR provides a mechanism for the detection, conjugation and subsequent elimination of toxic bile acids.

References[edit]

  1. ^ "Entrez Gene: UGT2B4 UDP glucuronosyltransferase 2 family, polypeptide B4". 
  2. ^ Jackson MR, McCarthy LR, Harding D, Wilson S, Coughtrie MW, Burchell B (March 1987). "Cloning of a human liver microsomal UDP-glucuronosyltransferase cDNA". Biochem. J. 242 (2): 581–8. PMC 1147744. PMID 3109396. 
  3. ^ Monaghan G, Clarke DJ, Povey S, See CG, Boxer M, Burchell B (September 1994). "Isolation of a human YAC contig encompassing a cluster of UGT2 genes and its regional localization to chromosome 4q13". Genomics 23 (2): 496–9. doi:10.1006/geno.1994.1531. PMID 7835904. 
  4. ^ Barre L, Fournel-Gigleux S, Finel M, Netter P, Magdalou J, Ouzzine M (March 2007). "Substrate specificity of the human UDP-glucuronosyltransferase UGT2B4 and UGT2B7. Identification of a critical aromatic amino acid residue at position 33". FEBS J. 274 (5): 1256–64. doi:10.1111/j.1742-4658.2007.05670.x. PMID 17263731. 
  5. ^ Barbier O, Torra IP, Sirvent A, Claudel T, Blanquart C, Duran-Sandoval D, Kuipers F, Kosykh V, Fruchart JC, Staels B (June 2003). "FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity". Gastroenterology 124 (7): 1926–40. doi:10.1016/S0016-5085(03)00388-3. PMID 12806625. 

Further reading[edit]