UH-301

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UH-301
UH-301 structure.png
Systematic (IUPAC) name
(S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin
Clinical data
Legal status ?
Identifiers
CAS number 127126-22-1 YesY
ATC code ?
IUPHAR ligand 61
Chemical data
Formula C16H24FNO 
Mol. mass 265.365 g/mol
 YesY (what is this?)  (verify)

UH-301 is a drug and research chemical widely used in scientific studies. It acts as a selective 5-HT1A receptor silent antagonist.[1] It is structurally related to 8-OH-DPAT.[1] UH-301 was found to produce a head-twitch response in mice which is usually typical of 5-HT2A agonist drugs, and has subsequently been used to investigate how 5-HT1A receptor activity modulates 5-HT2A receptors downstream.[2]

See also[edit]

References[edit]

  1. ^ a b Björk L, Cornfield LJ, Nelson DL, Hillver SE, Andén NE, Lewander T, Hacksell U. (1991). "Pharmacology of the novel 5-hydroxytryptamine1A receptor antagonist (S)-5-fluoro-8-hydroxy-2-(dipropylamino)tetralin: inhibition of (R)-8-hydroxy-2-(dipropylamino)tetralin-induced effects.". J Pharmacol Exp Ther. 258 (1): 58–65. PMID 1830099. 
  2. ^ Darmani, N. A.; Reeves, S. L. (1996). "The mechanism by which the selective 5-HT1A receptor antagonist S-(-) UH 301 produces head-twitches in mice". Pharmacology, biochemistry, and behavior 55 (1): 1–10. doi:10.1016/0091-3057(96)00072-X. PMID 8870031.  edit