From Wikipedia, the free encyclopedia
Jump to: navigation, search
Ubiquitin-like with PHD and ring finger domains 1
Protein UHRF1 PDB 2faz.png
PDB rendering based on 2faz.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols UHRF1 ; ICBP90; Np95; RNF106; hNP95; hUHRF1
External IDs OMIM607990 MGI1338889 HomoloGene7866 GeneCards: UHRF1 Gene
EC number
RNA expression pattern
PBB GE UHRF1 gnf1h00130 at tn.png
More reference expression data
Species Human Mouse
Entrez 29128 18140
Ensembl ENSG00000034063 ENSMUSG00000001228
UniProt Q96T88 Q8VDF2
RefSeq (mRNA) NM_001048201 NM_001111078
RefSeq (protein) NP_001041666 NP_001104548
Location (UCSC) Chr 19:
4.91 – 4.96 Mb
Chr 17:
56.3 – 56.32 Mb
PubMed search [1] [2]

Ubiquitin-like, containing PHD and RING finger domains, 1, also known as UHRF1, is a protein which in humans is encoded by the UHRF1 gene.[1][2]


This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits the main DNA methyltransferase gene, DNMT1, to regulate chromatin structure and gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase II alpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. Multiple transcript variants encoding different isoforms have been found for this gene.[1]

Clinical significance[edit]

UHRF1 has recently been identified as a novel oncogene in hepatocellular carcinoma, the primary type of liver cancer.[3]


Further reading[edit]