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Ubiquitin-like with PHD and ring finger domains 2, E3 ubiquitin protein ligase
Protein UHRF2 PDB 1wy8.png
PDB rendering based on 1wy8.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols UHRF2 ; NIRF; RNF107; URF2
External IDs OMIM615211 MGI1923718 HomoloGene17001 GeneCards: UHRF2 Gene
Species Human Mouse
Entrez 115426 109113
Ensembl ENSG00000147854 ENSMUSG00000024817
UniProt Q96PU4 Q7TMI3
RefSeq (mRNA) NM_152896 NM_144873
RefSeq (protein) NP_690856 NP_659122
Location (UCSC) Chr 9:
6.41 – 6.51 Mb
Chr 19:
30.03 – 30.09 Mb
PubMed search [1] [2]

E3 ubiquitin-protein ligase UHRF2 is an enzyme that in humans is encoded by the UHRF2 gene.[1][2]

This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis.[2]


  1. ^ Mori T, Li Y, Hata H, Ono K, Kochi H (Aug 2002). "NIRF, a novel RING finger protein, is involved in cell-cycle regulation". Biochem Biophys Res Commun 296 (3): 530–6. doi:10.1016/S0006-291X(02)00890-2. PMID 12176013. 
  2. ^ a b "Entrez Gene: UHRF2 ubiquitin-like, containing PHD and RING finger domains, 2". 

Further reading[edit]