UK-432,097

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UK-432,097
Kekulé skeletal formula of UK-432,097
Identifiers
Abbreviations UK-432,097
CAS number 380221-63-6 YesY
PubChem 9833519
ChemSpider 8009243 N
Jmol-3D images Image 1
Properties
Molecular formula C40H47N11O6
Molar mass 777.87 g mol−1
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
 N (verify) (what is: YesY/N?)
Infobox references

UK-432,097 is a drug developed by Pfizer for the treatment of chronic obstructive pulmonary disease, which acts as a potent and selective agonist of the adenosine A2A receptor.[1] It was discontinued from clinical trials following poor efficacy results,[2] but its high selectivity has made it useful for detailed mapping of the internal structure of the A2A receptor.[3]

References[edit]

  1. ^ Russo, Cristina; Arcidiacono, Giuseppe; Polosa, Riccardo (2006). "Adenosine receptors: promising targets for the development of novel therapeutics and diagnostics for asthma". Fundamental and Clinical Pharmacology 20 (1): 9–19. doi:10.1111/j.1472-8206.2005.00388.x. PMID 16448391.  edit
  2. ^ Safety And Efficacy Of UK-432,097 In Chronic Obstructive Pulmonary Disease. ClinicalTrials.gov
  3. ^ Xu F, Wu H, Katritch V, Han GW, Jacobson KA, Gao ZG, Cherezov V, Stevens RC (March 2011). "Structure of an Agonist-Bound Human A2A Adenosine Receptor". Science 332 (6027): 322–7. doi:10.1126/science.1202793. PMC 3086811. PMID 21393508.