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UL16 binding protein 2
Symbols ULBP2 ; N2DL2; RAET1H
External IDs OMIM605698 HomoloGene130743 GeneCards: ULBP2 Gene
RNA expression pattern
PBB GE ULBP2 221291 at tn.png
More reference expression data
Species Human Mouse
Entrez 80328 n/a
Ensembl ENSG00000131015 n/a
UniProt Q9BZM5 n/a
RefSeq (mRNA) NM_025217 n/a
RefSeq (protein) NP_079493 n/a
Location (UCSC) Chr 6:
150.26 – 150.27 Mb
PubMed search [1] n/a

NKG2D ligand 2 is a protein that in humans is encoded by the ULBP2 gene.[1][2] It is a stress induced ligand for the NK cell activating receptor NKG2D.[3]


  1. ^ Cosman D, Mullberg J, Sutherland CL, Chin W, Armitage R, Fanslow W, Kubin M, Chalupny NJ (Mar 2001). "ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor". Immunity 14 (2): 123–33. doi:10.1016/S1074-7613(01)00095-4. PMID 11239445. 
  2. ^ "Entrez Gene: ULBP2 UL16 binding protein 2". 
  3. ^ González, S et al. (2008). "NKG2D ligands: key targets of the immune response". Trends in Immunology 29 (8): 397–403. doi:10.1016/j.it.2008.04.007. PMID 18602338. 

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