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UL16 binding protein 3
Protein ULBP3 PDB 1kcg.png
PDB rendering based on 1kcg.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols ULBP3 ; RAET1N
External IDs OMIM605699 HomoloGene129737 GeneCards: ULBP3 Gene
Species Human Mouse
Entrez 79465 n/a
Ensembl ENSG00000131019 n/a
UniProt Q9BZM4 n/a
RefSeq (mRNA) NM_024518 n/a
RefSeq (protein) NP_078794 n/a
Location (UCSC) Chr 6:
150.38 – 150.39 Mb
PubMed search [1] n/a

NKG2D ligand 3 is a protein that in humans is encoded by the ULBP3 gene.[1][2][3] It is a stress induced ligand for the NK cell activating receptor NKG2D.[4]


  1. ^ Cosman D, Mullberg J, Sutherland CL, Chin W, Armitage R, Fanslow W, Kubin M, Chalupny NJ (Mar 2001). "ULBPs, novel MHC class I-related molecules, bind to CMV glycoprotein UL16 and stimulate NK cytotoxicity through the NKG2D receptor". Immunity 14 (2): 123–33. doi:10.1016/S1074-7613(01)00095-4. PMID 11239445. 
  2. ^ Radosavljevic M, Cuillerier B, Wilson MJ, Clement O, Wicker S, Gilfillan S, Beck S, Trowsdale J, Bahram S (Feb 2002). "A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3". Genomics 79 (1): 114–23. doi:10.1006/geno.2001.6673. PMID 11827464. 
  3. ^ "Entrez Gene: ULBP3 UL16 binding protein 3". 
  4. ^ González, S et al. (2008). "NKG2D ligands: key targets of the immune response". Trends in Immunology 29 (8): 397–403. doi:10.1016/j.it.2008.04.007. PMID 18602338. 

Further reading[edit]