ULK1

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Unc-51 like autophagy activating kinase 1
Identifiers
Symbols ULK1 ; ATG1; ATG1A; UNC51; Unc51.1; hATG1
External IDs OMIM603168 MGI1270126 HomoloGene2640 ChEMBL: 6006 GeneCards: ULK1 Gene
EC number 2.7.11.1
RNA expression pattern
PBB GE ULK1 209333 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 8408 22241
Ensembl ENSG00000177169 ENSMUSG00000029512
UniProt O75385 O70405
RefSeq (mRNA) NM_003565 NM_009469
RefSeq (protein) NP_003556 NP_033495
Location (UCSC) Chr 12:
132.38 – 132.41 Mb
Chr 5:
110.78 – 110.81 Mb
PubMed search [1] [2]

Serine/threonine-protein kinase ULK1 is an enzyme that in humans is encoded by the ULK1 gene.[1][2]


Interactions[edit]

ULK1 has been shown to interact with GABARAPL2,[3] GABARAP,[3][4] SYNGAP1[5] and SDCBP.[5]

References[edit]

  1. ^ Kuroyanagi H, Yan J, Seki N, Yamanouchi Y, Suzuki Y, Takano T, Muramatsu M, Shirasawa T (September 1998). "Human ULK1, a novel serine/threonine kinase related to UNC-51 kinase of Caenorhabditis elegans: cDNA cloning, expression, and chromosomal assignment". Genomics 51 (1): 76–85. doi:10.1006/geno.1998.5340. PMID 9693035. 
  2. ^ "Entrez Gene: ULK1 unc-51-like kinase 1 (C. elegans)". 
  3. ^ a b Okazaki, N; Yan J; Yuasa S; Ueno T; Kominami E; Masuho Y; Koga H; Muramatsu M (December 2000). "Interaction of the Unc-51-like kinase and microtubule-associated protein light chain 3 related proteins in the brain: possible role of vesicular transport in axonal elongation". Brain Res. Mol. Brain Res. (Netherlands) 85 (1–2): 1–12. doi:10.1016/S0169-328X(00)00218-7. ISSN 0169-328X. PMID 11146101. 
  4. ^ Ewing, Rob M; Chu Peter, Elisma Fred, Li Hongyan, Taylor Paul, Climie Shane, McBroom-Cerajewski Linda, Robinson Mark D, O'Connor Liam, Li Michael, Taylor Rod, Dharsee Moyez, Ho Yuen, Heilbut Adrian, Moore Lynda, Zhang Shudong, Ornatsky Olga, Bukhman Yury V, Ethier Martin, Sheng Yinglun, Vasilescu Julian, Abu-Farha Mohamed, Lambert Jean-Philippe, Duewel Henry S, Stewart Ian I, Kuehl Bonnie, Hogue Kelly, Colwill Karen, Gladwish Katharine, Muskat Brenda, Kinach Robert, Adams Sally-Lin, Moran Michael F, Morin Gregg B, Topaloglou Thodoros, Figeys Daniel (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. (England) 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931. 
  5. ^ a b Tomoda, Toshifumi; Kim Jee Hae; Zhan Caixin; Hatten Mary E (March 2004). "Role of Unc51.1 and its binding partners in CNS axon outgrowth". Genes Dev. (United States) 18 (5): 541–58. doi:10.1101/gad.1151204. ISSN 0890-9369. PMC 374236. PMID 15014045. 

Further reading[edit]