Unc-51-like kinase 2 (C. elegans) also known as ULK2 is an enzyme which in humans is encoded by the ULK2 gene. The gene is located within the [1 ] Smith-Magenis syndrome region on chromosome 17.
Structure and function [ edit ]
This gene encodes a protein that is similar to a
serine/threonine kinase in which is involved in C. elegans axonal elongation. The structure of this protein is similar to the C. elegans protein in that both proteins have an N-terminal kinase domain, a central proline/ serine rich (PS) domain, and a C-terminal (C) domain. ULK2 and the [2 ] GTPase activating protein SynGAP function cooperatively in axon formation. [3 ]
References [ edit ]
^ Yan J, Kuroyanagi H, Tomemori T, Okazaki N, Asato K, Matsuda Y, Suzuki Y, Ohshima Y, Mitani S, Masuho Y, Shirasawa T, Muramatsu M (October 1999). "Mouse ULK2, a novel member of the UNC-51-like protein kinases: unique features of functional domains". Oncogene 18 (43): 5850–9. doi: 10.1038/sj.onc.1202988. PMID 10557072.
^ "Entrez Gene: ULK2".
^ Tomoda T, Kim JH, Zhan C, Hatten ME (March 2004). "Role of Unc51.1 and its binding partners in CNS axon outgrowth". Genes Dev. 18 (5): 541–58. doi: 10.1101/gad.1151204. PMC 374236. PMID 15014045.
External links [ edit ]
This article incorporates text from the United States National Library of Medicine, which is in the public domain.