UPB1

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Ureidopropionase, beta
Identifiers
Symbols UPB1 ; BUP1
External IDs OMIM606673 MGI2143535 HomoloGene9471 GeneCards: UPB1 Gene
EC number 3.5.1.6
RNA expression pattern
PBB GE UPB1 220507 s at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 51733 103149
Ensembl ENSG00000100024 ENSMUSG00000033427
UniProt Q9UBR1 Q8VC97
RefSeq (mRNA) NM_016327 NM_133995
RefSeq (protein) NP_057411 NP_598756
Location (UCSC) Chr 22:
24.86 – 24.92 Mb
Chr 10:
75.41 – 75.44 Mb
PubMed search [1] [2]

Beta-ureidopropionase is an enzyme that in humans is encoded by the UPB1 gene.[1][2]

This gene encodes a protein that belongs to the CN hydrolase family. Beta-ureidopropionase catalyzes the last step in the pyrimidine degradation pathway. The pyrimidine bases uracil and thymine are degraded via the consecutive action of dihydropyrimidine dehydrogenase (DHPDH), dihydropyrimidinase (DHP) and beta-ureidopropionase (UP) to beta-alanine and beta-aminoisobutyric acid, respectively. UP deficiencies are associated with N-carbamyl-beta-amino aciduria and may lead to abnormalities in neurological activity.[2]

Interactive pathway map[edit]

Click on genes, proteins and metabolites below to link to respective articles. [§ 1]

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FluoropyrimidineActivity_WP1601 go to article go to article go to article go to pathway article go to pathway article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to PubChem Compound go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to pathway article go to pathway article go to article go to article go to article go to article go to article go to WikiPathways go to article go to article go to article go to article go to article go to article go to article go to article go to article
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FluoropyrimidineActivity_WP1601 go to article go to article go to article go to pathway article go to pathway article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to PubChem Compound go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to article go to pathway article go to pathway article go to article go to article go to article go to article go to article go to WikiPathways go to article go to article go to article go to article go to article go to article go to article go to article go to article
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Fluorouracil (5-FU) Activity edit
  1. ^ The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601". 

References[edit]

  1. ^ Vreken P, van Kuilenburg AB, Hamajima N, Meinsma R, van Lenthe H, Gohlich-Ratmann G, Assmann BE, Wevers RA, van Gennip AH (Dec 1999). "cDNA cloning, genomic structure and chromosomal localization of the human BUP-1 gene encoding beta-ureidopropionase". Biochim Biophys Acta 1447 (2–3): 251–7. doi:10.1016/s0167-4781(99)00182-7. PMID 10542323. 
  2. ^ a b "Entrez Gene: UPB1 ureidopropionase, beta". 

Further reading[edit]