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Ubiquitin specific peptidase 33
Protein USP33 PDB 2uzg.png
PDB rendering based on 2uzg.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols USP33 ; VDU1
External IDs OMIM615146 MGI2159711 HomoloGene8996 GeneCards: USP33 Gene
EC number
RNA expression pattern
PBB GE USP33 212513 s at tn.png
PBB GE USP33 214843 s at tn.png
More reference expression data
Species Human Mouse
Entrez 23032 170822
Ensembl ENSG00000077254 ENSMUSG00000025437
UniProt Q8TEY7 Q8R5K2
RefSeq (mRNA) NM_015017 NM_001076676
RefSeq (protein) NP_055832 NP_001070144
Location (UCSC) Chr 1:
78.16 – 78.23 Mb
Chr 3:
152.35 – 152.39 Mb
PubMed search [1] [2]

Ubiquitin carboxyl-terminal hydrolase 33 is an enzyme that in humans is encoded by the USP33 gene.[1][2]


USP33 has been shown to interact with DIO2,[3] SELENBP1[4] and Von Hippel-Lindau tumor suppressor.[5]


  1. ^ Puente XS, Sánchez LM, Overall CM, López-Otín C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet 4 (7): 544–558. doi:10.1038/nrg1111. PMID 12838346. 
  2. ^ "Entrez Gene: USP33 ubiquitin specific peptidase 33". 
  3. ^ Curcio-Morelli C, Zavacki AM, Christofollete M, Gereben B, de Freitas BC, Harney JW et al. (Jul 2003). "Deubiquitination of type 2 iodothyronine deiodinase by von Hippel-Lindau protein-interacting deubiquitinating enzymes regulates thyroid hormone activation". J. Clin. Invest. 112 (2): 189–196. doi:10.1172/JCI18348. PMC 164294. PMID 12865408. 
  4. ^ Jeong JY, Wang Y, Sytkowski AJ (Feb 2009). "Human selenium binding protein-1 (hSP56) interacts with VDU1 in a selenium-dependent manner". Biochem. Biophys. Res. Commun. 379 (2): 583–588. doi:10.1016/j.bbrc.2008.12.110. PMID 19118533. 
  5. ^ Li Z, Na X, Wang D, Schoen SR, Messing EM, Wu G (Feb 2002). "Ubiquitination of a novel deubiquitinating enzyme requires direct binding to von Hippel-Lindau tumor suppressor protein". J. Biol. Chem. 277 (7): 4656–4662. doi:10.1074/jbc.M108269200. PMID 11739384. 

Further reading[edit]