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Ubiquitin specific peptidase 36
Symbols USP36 ; DUB1
External IDs OMIM612543 MGI1919594 HomoloGene11828 GeneCards: USP36 Gene
EC number
RNA expression pattern
PBB GE USP36 220370 s at tn.png
More reference expression data
Species Human Mouse
Entrez 57602 72344
Ensembl ENSG00000055483 ENSMUSG00000033909
UniProt Q9P275 B1AQJ2
RefSeq (mRNA) NM_025090 NM_001033528
RefSeq (protein) NP_079366 NP_001028700
Location (UCSC) Chr 17:
76.78 – 76.84 Mb
Chr 11:
118.26 – 118.29 Mb
PubMed search [1] [2]

Ubiquitin-specific protease 36 is an enzyme that in humans is encoded by the USP36 gene. [1] [2]

This gene encodes a member of the ubiquitin-specific protease family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the nucleoli and deubuquitinate nucleophosmin and fibrillarin[3]


  1. ^ Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet 4 (7): 544–558. doi:10.1038/nrg1111. PMID 12838346. 
  2. ^ "Entrez Gene: USP36 ubiquitin specific peptidase 36". 
  3. ^ Endo A, Matsumoto M, Inada T, Yamamoto A, Nakayama KI, Kitamura N, Komada M. (Mar 2009). "Nucleolar structure and function are regulated by the deubiquitylating enzyme USP36.". J Cell Sci. 122 (Pt 5): 678–86. doi:10.1242/jcs.044461. PMID 19208757. 

Further reading[edit]