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Ubiquitin specific peptidase 5 (isopeptidase T)
Protein USP5 PDB 2dag.png
PDB rendering based on 2dag.
Available structures
PDB Ortholog search: PDBe, RCSB
Symbols USP5 ; ISOT
External IDs OMIM601447 MGI1347343 HomoloGene55758 IUPHAR: 2431 ChEMBL: 6158 GeneCards: USP5 Gene
EC number
RNA expression pattern
PBB GE USP5 206031 s at tn.png
More reference expression data
Species Human Mouse
Entrez 8078 22225
Ensembl ENSG00000111667 ENSMUSG00000038429
UniProt P45974 P56399
RefSeq (mRNA) NM_001098536 NM_013700
RefSeq (protein) NP_001092006 NP_038728
Location (UCSC) Chr 12:
6.96 – 6.98 Mb
Chr 6:
124.82 – 124.83 Mb
PubMed search [1] [2]

Ubiquitin specific peptidase 5 is an enzyme that in humans is encoded by the USP5 gene.[1][2][3]


USP5 has been shown to interact with TADA3L.[4]


  1. ^ Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346. 
  2. ^ Ansari-Lari MA, Muzny DM, Lu J, Lu F, Lilley CE, Spanos S, Malley T, Gibbs RA (Sep 1996). "A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13". Genome Res 6 (4): 314–26. doi:10.1101/gr.6.4.314. PMID 8723724. 
  3. ^ "Entrez Gene: USP5 ubiquitin specific peptidase 5 (isopeptidase T)". 
  4. ^ Rual, Jean-François; Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc (Oct 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature (England) 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 

Further reading[edit]