USP6

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Ubiquitin specific peptidase 6 (Tre-2 oncogene)
Identifiers
Symbols USP6 ; HRP1; TRE17; TRE2; Tre-2; USP6-short
External IDs OMIM604334 GeneCards: USP6 Gene
EC number 3.4.19.12
RNA expression pattern
PBB GE USP6 206405 x at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 9098 n/a
Ensembl ENSG00000129204 n/a
UniProt P35125 n/a
RefSeq (mRNA) NM_004505 n/a
RefSeq (protein) NP_004496 n/a
Location (UCSC) Chr 17:
5.02 – 5.08 Mb
n/a
PubMed search [1] n/a

Ubiquitin carboxyl-terminal hydrolase 6 is an enzyme that in humans is encoded by the USP6 gene.[1][2][3]

Aneurysmal bone cyst can be associated with a TRE17/USP6 translocation.[4]


References[edit]

  1. ^ Puente XS, Sanchez LM, Overall CM, Lopez-Otin C (Jul 2003). "Human and mouse proteases: a comparative genomic approach". Nat Rev Genet 4 (7): 544–58. doi:10.1038/nrg1111. PMID 12838346. 
  2. ^ Hoogendijk JE, Hensels GW, Gabreels-Festen AA, Gabreels FJ, Janssen EA, de Jonghe P, Martin JJ, van Broeckhoven C, Valentijn LJ, Baas F, et al. (May 1992). "De-novo mutation in hereditary motor and sensory neuropathy type I". Lancet 339 (8801): 1081–2. doi:10.1016/0140-6736(92)90668-S. PMID 1349106. 
  3. ^ "Entrez Gene: USP6 ubiquitin specific peptidase 6 (Tre-2 oncogene)". 
  4. ^ Ye Y, Pringle LM, Lau AW, et al. (June 2010). "TRE17/USP6 oncogene translocated in aneurysmal bone cyst induces matrix metalloproteinase production via activation of NFκB". Oncogene 29 (25): 3619–29. doi:10.1038/onc.2010.116. PMC 2892027. PMID 20418905. 

Further reading[edit]