USP6

Ubiquitin specific peptidase 6 (Tre-2 oncogene)
Identifiers
Symbols	USP6; HRP1; TRE17; TRE2; Tre-2; USP6-short
External IDs	OMIM: 604334 GeneCards: USP6 Gene
EC number	3.4.19.12
Gene Ontology Molecular function • nucleic acid binding • cysteine-type endopeptidase activity • ubiquitin thiolesterase activity • ubiquitin-specific protease activity • Rab GTPase activator activity • protein binding • calmodulin binding • peptidase activity Cellular component • intracellular • cytoplasm • lysosome • plasma membrane • recycling endosome Biological process • protein modification process • ubiquitin-dependent protein catabolic process • protein deubiquitination • regulation of vesicle-mediated transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9098	n/a
Ensembl	ENSG00000129204	n/a
UniProt	P35125	n/a
RefSeq (mRNA)	XM_001134439	n/a
RefSeq (protein)	XP_001134439	n/a
Location (UCSC)	Chr 17: 5.02 – 5.08 Mb	n/a
PubMed search	[1]	n/a

Ubiquitin carboxyl-terminal hydrolase 6 is an enzyme that in humans is encoded by the USP6 gene.

Aneurysmal bone cyst can be associated with a TRE17/USP6 translocation.

Further reading

• D'Andrea A, Pellman D (1999). "Deubiquitinating enzymes: a new class of biological regulators". Crit. Rev. Biochem. Mol. Biol. 33 (5): 337–52. doi:10.1080/10409239891204251. PMID 9827704. 
• Nakamura T, Hillova J, Mariage-Samson R, et al. (1992). "A novel transcriptional unit of the tre oncogene widely expressed in human cancer cells". Oncogene 7 (4): 733–41. PMID 1565468. 
• Papa FR, Hochstrasser M (1993). "The yeast DOA4 gene encodes a deubiquitinating enzyme related to a product of the human tre-2 oncogene". Nature 366 (6453): 313–9. doi:10.1038/366313a0. PMID 8247125. 
• Onno M, Nakamura T, Hillova J, Hill M (1993). "Identification of novel sequences in the repertoire of hypervariable TRE17 genes from immortalized nonmalignant and malignant human keratinocytes". Gene 131 (2): 209–15. doi:10.1016/0378-1119(93)90295-E. PMID 8406013. 
• Onno M, Nakamura T, Mariage-Samson R, et al. (1993). "Human TRE17 oncogene is generated from a family of homologous polymorphic sequences by single-base changes". DNA Cell Biol. 12 (2): 107–18. doi:10.1089/dna.1993.12.107. PMID 8471161. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Paulding CA, Ruvolo M, Haber DA (2003). "The Tre2 (USP6) oncogene is a hominoid-specific gene". Proc. Natl. Acad. Sci. U.S.A. 100 (5): 2507–11. doi:10.1073/pnas.0437015100. PMC 151371. PMID 12604796. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=151371. 
• Masuda-Robens JM, Kutney SN, Qi H, Chou MM (2003). "The TRE17 Oncogene Encodes a Component of a Novel Effector Pathway for Rho GTPases Cdc42 and Rac1 and Stimulates Actin Remodeling". Mol. Cell. Biol. 23 (6): 2151–61. doi:10.1128/MCB.23.6.2151-2161.2003. PMC 149457. PMID 12612085. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=149457. 
• Bizimungu C, De Neve N, Burny A, et al. (2003). "Expression in a RabGAP yeast mutant of two human homologues, one of which is an oncogene". Biochem. Biophys. Res. Commun. 310 (2): 498–504. doi:10.1016/j.bbrc.2003.09.051. PMID 14521938. 
• Oliveira AM, Hsi BL, Weremowicz S, et al. (2004). "USP6 (Tre2) fusion oncogenes in aneurysmal bone cyst". Cancer Res. 64 (6): 1920–3. doi:10.1158/0008-5472.CAN-03-2827. PMID 15026324. 
• Oliveira AM, Perez-Atayde AR, Inwards CY, et al. (2004). "USP6 and CDH11 oncogenes identify the neoplastic cell in primary aneurysmal bone cysts and are absent in so-called secondary aneurysmal bone cysts". Am. J. Pathol. 165 (5): 1773–80. doi:10.1016/S0002-9440(10)63432-3. PMID 15509545. 
• Martinu L, Masuda-Robens JM, Robertson SE, et al. (2004). "The TBC (Tre-2/Bub2/Cdc16) Domain Protein TRE17 Regulates Plasma Membrane-Endosomal Trafficking through Activation of Arf6". Mol. Cell. Biol. 24 (22): 9752–62. doi:10.1128/MCB.24.22.9752-9762.2004. PMC 525471. PMID 15509780. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=525471. 
• Oliveira AM, Perez-Atayde AR, Dal Cin P, et al. (2005). "Aneurysmal bone cyst variant translocations upregulate USP6 transcription by promoter swapping with the ZNF9, COL1A1, TRAP150, and OMD genes". Oncogene 24 (21): 3419–26. doi:10.1038/sj.onc.1208506. PMID 15735689. 
• Bizimungu C, Vandenbol M (2005). "At least two regions of the oncoprotein Tre2 are involved in its lack of GAP activity". Biochem. Biophys. Res. Commun. 335 (3): 883–90. doi:10.1016/j.bbrc.2005.07.159. PMID 16099424. 
• Shen C, Ye Y, Robertson SE, et al. (2006). "Calcium/calmodulin regulates ubiquitination of the ubiquitin-specific protease TRE17/USP6". J. Biol. Chem. 280 (43): 35967–73. doi:10.1074/jbc.M505220200. PMID 16127172. 
• Dechamps C, Bach S, Portetelle D, Vandenbol M (2006). "The Tre2 oncoprotein, implicated in Ewing's sarcoma, interacts with two components of the cytoskeleton". Biotechnol. Lett. 28 (4): 223–31. doi:10.1007/s10529-005-5523-2. PMID 16555005.