Ubiquitin B

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Ubiquitin B
Protein UBB PDB 1aar.png
PDB rendering based on 1aar.
Available structures
PDB Ortholog search: PDBe, RCSB
Identifiers
Symbols UBB ; RPS27A; UBA52; UBC
External IDs OMIM191339 HomoloGene75104 GeneCards: UBB Gene
RNA expression pattern
PBB GE UBB 200633 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 7314 n/a
Ensembl ENSG00000170315 n/a
UniProt P0CG47 n/a
RefSeq (mRNA) NM_001281716 n/a
RefSeq (protein) NP_001268645 n/a
Location (UCSC) Chr 17:
16.28 – 16.29 Mb
n/a
PubMed search [1] n/a

Ubiquitin is a protein that in humans is encoded by the UBB gene.[1]

Function[edit]

Ubiquitin is one of the most conserved proteins known in eukaryotic organisms. Ubiquitin is required for ATP-dependent, non-lysosomal intracellular protein degradation of abnormal proteins and normal proteins with a rapid turnover. Ubiquitin is covalently bound to proteins to be degraded, and presumably labels these proteins for degradation. Ubiquitin also binds to histone H2A in actively transcribed regions but does not cause histone H2A degradation, suggesting that ubiquitin is also involved in regulation of gene expression. This gene consists of three direct repeats of the ubiquitin coding sequence with no spacer sequence. Consequently, the protein is expressed as a polyubiquitin precursor with a final amino acid after the last repeat. Aberrant form of this protein (UBB+1) has been noticed in patients with Alzheimer's disease, Down syndrome, other tauopathies (e.g. Pick's disease) and polyglutamine disease (e.g. Huntington's disease).[2][3]

References[edit]

  1. ^ Webb GC, Baker RT, Fagan K, Board PG (Mar 1990). "Localization of the human UbB polyubiquitin gene to chromosome band 17p11.1-17p12". Am J Hum Genet 46 (2): 308–15. PMC 1684968. PMID 2154095. 
  2. ^ Fischer DF, De Vos RA, Van Dijk R, De Vrij FM, Proper EA, Sonnemans MA, Verhage MC, Sluijs JA, Hobo B, Zouambia M, Steur EN, Kamphorst W, Hol EM, Van Leeuwen FW (Nov 2003). "Disease-specific accumulation of mutant ubiquitin as a marker for proteasomal dysfunction in the brain". FASEB J 17 (14): 2014–2024. doi:10.1096/fj.03-0205com. PMID 14597671. 
  3. ^ "Entrez Gene: UBB ubiquitin B". 

Further reading[edit]