He was born in Männedorf and studied Protestant theology in Zurich, Göttingen and Basel under Hans Conzelmann, Eduard Schweizer, and Gerhard Ebeling. He taught at the International Christian University in Tokyo from 1970-1971. From 1972 to 1980 he was professor of New Testament at Göttingen, then became professor of New Testament in Bern in Switzerland in 2003.
Much of his research has focused on the Gospel of Matthew, and he has seven honorary doctorates. He served as president of the Societas Novi Testamenti Studiorum in 1998.
He and his wife, Salome Keller, have three children.
- Das Geschichtsverstandnis des Paulus 1968
- Die Mitte des Neuen Testaments: Einheit und Vielfalt neutestamentlich 1983
- Matthew. 3 vols. 1989, 2001, 2005 ISBN 0-8006-9600-X; ISBN 0-8006-6034-X; ISBN 0-8006-3770-4
- Matthew in History: Interpretation, Influence and Effects by Ulrich Luz 1994 ISBN 0-8006-2833-0
- The Theology of the Gospel of Matthew by Ulrich Luz and J. Bradford Robinson 1995 ISBN 0-521-43576-5
- Studies In Matthew by Ulrich Luz and Rosemary Selle 2005 ISBN 0-8028-3964-9
- "The Bible in a World Context: An Experiment in Contextual Hermeneutics" with Walter Dietrich ISBN 0-8028-4988-1, 9-7808-0284-988-5
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