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Uncle Frank may refer to:
- The security guard, played by Frank Potenza (1933-2011) on Jimmy Kimmel Live!
- One of the alternative stage names of Frank Benbini, the drummer of the Fun Lovin' Criminals
- The band Uncle Frank for which Frank Benbini plays
- Kevin McCallister's uncle from Home Alone
- A term of endearment often used in reference to the musician Frank Zappa
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