Elton John's performance on February 8, 2000 was the first concert to be held at United Spirit Arena.
In the summer of 2002, Britney Spears brought her Dream Within a Dream Tour to the arena. After the second song, "(You Drive Me) Crazy", a power outage occurred and the rest of the concert had to be canceled. Spears, along with her tour manager, came onstage to explain the situation to the sold out crowd. Due to Spears being overbooked for the entire tour, there was no time to reschedule the concert.
United Spirit Arena hosted WWE RAW (the first RAW ever to be hosted in Lubbock) in May 2006.
On January 1, 2007, a 70–68 defeat of the New Mexico Lobos by the Texas Tech Red Raiders marked the 880th total win for Bob Knight, making him the winningest coach in men's college basketball history.
On October 14, 2011, Taylor Swift made her first ever appearance at the United Spirit Arena with her Speak Now World Tour. Tickets for the show were sold out within twenty minutes after going on sale, the fastest sell-out in United Spirit Arena history.
On January 18, 2013, the United Spirit Arena hosted to first show in the final live tour of George Strait. He was supported by Martina McBride.