The United States Attorney's Office for the Middle District of Louisiana represents the United States in civil and criminal litigation in the court. The current U.S. Attorney for the District is Don Cazayoux.
On February 13, 1845, Louisiana was reorganized into a single District with one judgeship, by 5 Stat. 722, but was again divided into Eastern and the Western Districts on March 3, 1849, by 9 Stat. 401. Congress again abolished the Western District of Louisiana and reorganized Louisiana as a single judicial district on July 27, 1866, by 14 Stat. 300. On March 3, 1881, by 21 Stat. 507, Louisiana was for a third time divided into Eastern and the Western Districts, with one judgeship authorized for each. The Middle District was formed from portions of those two Districts on December 18, 1971, by 85 Stat. 741, making it one of the youngest districts in the United States.