The 2000 South Carolina United States House of Representatives elections were held on November 7, 2000 to select six Representatives for two-year terms from the state of South Carolina. The primary elections for the Democrats and the Republicans were held on June 13 and the runoff elections were held two weeks later on June 27. All five incumbents who ran were re-elected and the open seat in the 1st congressional district was retained by the Republicans. The composition of the state delegation remained four Republicans and two Democrats.
Incumbent Republican Congressman Mark Sanford of the 1st congressional district, in office since 1995, honored his campaign pledge that he would only serve three terms and retired. Henry E. Brown, Jr. won the Republican primary and defeated Democrat Andy Brack in the general election.
Incumbent Republican Congressman Jim DeMint of the 4th congressional district, in office since 1999, defeated Franklin D. Raddish in the Republican primary and won the general election against several minor party candidates.