The 2000 United States Senate election in Michigan was held on November 7, 2000. Incumbent Republican U.S. Senator Spencer Abraham ran for re-election to a second term, but was defeated by Democrat Debbie Stabenow.
Abraham, who was first elected in the 1994 Republican Revolution despite never running for public office before, was considered vulnerable by the Democratic Senatorial Campaign Committee. Major issues in the campaign included prescription drugs for the elderly. By September 4, Abraham still had failed to reach 50% in polls despite having spent over $6 million on television ads. In mid-October, he came back and reached 50% and 49% in two polls respectively.