The 1980 United States Senate election in Nevada was held on November 4, 1980. Incumbent Democratic U.S. Senator Alan Bible decided to retire instead of seeking a fourth full term. Republican nominee Paul Laxalt won the open seat.
Laxalt won by less than 700 votes, becoming one of the few bright spots in a bad year for Republicans. Bible resigned three weeks early (on December 17, 1974) and on one day later Nevada Democratic Governor Mike O'Callaghan appointed Laxalt to finish out that term. When Laxalt retired in 1986, Harry Reid won the seat that he lost in this election.