The meaning of "Unskinny Bop" has always been shrouded in obscurity. C.C. DeVille later confessed that the phrase "unskinny bop" has no particular meaning. He invented it as a temporary measure while writing the song, before vocalist Bret Michaels had begun working on the lyrics. The phrase was used on the basis that it was phonetically suited to the music. The song was later played to producer Fairbairn, who stated that, although he did not know what an "unskinny bop" was, the phrase was perfect.
On the HBO series Eastbound & Down, Kenny Powers used the song as his entrance theme while riding on a donkey to the field and throwing beer to the crowd.
In his book A Lion's Tale: Around the World in Spandex, professional wrestler Chris Jericho states that he used Unskinny Bop as his entrance theme in his first professional match, and continued to use it as theme music while wrestling on the Canadian independent circuit in the early 1990s.