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The term upstate may refer to the northerly portions of several U.S. states. It also can refer to parts of states that have a higher elevation, away from sea level. These regions tend to be rural; an exception is Delaware.
- Maine, except for "Down East"
- Upstate California was a 2001 marketing campaign to promote the northern half of Northern California
- Upstate New York, an area of New York north of the New York City metropolitan area
- SUNY Upstate Medical University, often referred to as "Upstate"
- Upstate South Carolina, the northwestern "corner" of South Carolina
- Articles beginning with "Upstate"
- Downstate Illinois, which refers to the part of Illinois outside the Chicago metropolitan area
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