Ureaplasma urealyticum

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Ureaplasma urealyticum
Scientific classification
Kingdom: Bacteria
Division: Firmicutes
Class: Mollicutes
Order: Mycoplasmatales
Family: Mycoplasmataceae
Genus: Ureaplasma
Species: U. urealyticum
Binomial name
Ureaplasma urealyticum
Shepard et al., 1974

Ureaplasma urealyticum is a bacterium belonging to the family Mycoplasmataceae. Its type strain is T960.

Clinical significance[edit]

U. urealyticum is part of the normal genital flora of both men and women.[1] It is found in about 70% of sexually active humans.[2]

It had also been associated with a number of diseases in humans, including non-specific urethritis (NSU), infertility, chorioamnionitis, stillbirth, premature birth, and, in the perinatal period, pneumonia, bronchopulmonary dysplasia[3] and meningitis.

However, given the relatively low pathogenicity of the organism its role in some of these diseases remains contentious.

U. urealyticum has been noted as one of the infectious causes of sterile pyuria.[4]


There are six recognised Ureaplasma species, They have a GC content of 27–30%, and a genome size ranging between 0.76–1.17 Mbp, and cholesterol is required for growth. [5] A defining characteristic of the genus is that they perform urea hydrolysis.

It is now recommended that some strains originally classified as Ureaplasma urealyticum should be treated as a new species, U. parvum.


Doxycycline is the drug of choice but Azithromycin is also used as a 5 day course rather than a single dose that would be used to treat Chlamydia;[6] streptomycin is an alternative but is less popular because it must be injected. Penicillins are ineffective — U. urealyticum does not have a cell wall,[7] which is the drug's main target.[8]


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