Ureidopenicillin

From Wikipedia, the free encyclopedia
Jump to: navigation, search

The ureidopenicillins are a group of penicillins which are active against Pseudomonas aeruginosa.

There are three ureidopenicillins in clinical use:[1]

They are mostly ampicillin derivatives in which the D-side amino chain has been converted to a variety of ureas. It is speculated that the added side chain mimics a longer segment of the peptidoglycan chain, more than ampicillin, and thus would bind more easily to the penicillin-binding proteins. Ureidopenicillins are not resistant to beta-lactamases.

They are used parenterally, and are particularly indicated in infections caused by Gram-negative bacteria.

References[edit]

  1. ^ "Mayo Clinic Proceedings". Retrieved 2008-12-26. [dead link]