Urethral cancer

From Wikipedia, the free encyclopedia
Jump to: navigation, search
This article is about cancer of the urethra. For cancer of the ureter, see Ureteral cancer.
Urethral cancer
Classification and external resources
Urethral urothelial cell carcinoma.jpg
Micrograph of a urethral cancer, urothelial cell carcinoma, found on a prostate core biopsy. H&E stain.
DiseasesDB 31473
eMedicine med/3080
NCI Urethral cancer
MeSH D014523

Urethral cancer is cancer originating from the urethra. Cancer in this location is rare, and the most common type is papillary transitional cell carcinoma.[1]


Symptoms that may be caused by urethral cancer include:

  • Bleeding from the urethra or blood in the urine.
  • Weak or interrupted flow of urine.
  • Urination occurs often.
  • A lump or thickness in the perineum or penis.
  • Discharge from the urethra.
  • Enlarged lymph nodes in the groin area.
  • Most common site being bulbomembranous urethra.

Risk factors[edit]

  • Having a history of bladder cancer.
  • Having conditions that cause chronic, swollen, reddened part in the urethra.
  • Being 60 or older.
  • Being a white female.


Diagnosis is established by transurethral biopsy. Types of urethral cancer include transitional cell carcinoma, squamous cell carcinoma, adenocarcinoma, and melanoma.


Surgery is the most common treatment for cancer of the urethra. One of the following types of surgery may be done:

Chemotherapy as a form of Urethral Cancer Treatment

Chemotherapy involves using drugs to destroy urethral cancer cells. It is a systemic urethral cancer treatment (i.e., destroys urethral cancer cells throughout the body) that is administered orally or intravenously (through a vein; IV). Medications are often used in combination to destroy urethral cancer that has metastasized. Commonly used drugs include cisplatin (Platinol®), vincristine (Oncovin®), and methotrexate (Trexall®).

Side effects include the following:

Anemia (causing fatigue, weakness) Nausea and vomiting Loss of appetite (anorexia) Hair loss (alopecia) Mouth sores Increased risk for infection Shortness of breath Excessive bleeding and bruising [2]

See also[edit]


  1. ^ Ries, LAG; Young, JL; Keel, GE; Eisner, MP; Lin, YD; Horner, M-J, eds. (2007). "SEER Survival Monograph: Cancer Survival Among Adults: US SEER Program, 1988-2001, Patient and Tumor Characteristics". SEER Program. NIH Pub. No. 07-6215. Bethesda, MD: National Cancer Institute. pp. 251–262. Retrieved 18 October 2013.  |chapter= ignored (help)
  2. ^ Urethral Cancer Treatment