Uruguay made its Paralympic Games début at the 1992 Summer Paralympics in Barcelona, sending just two representatives to compete in track and field. The country has competed in every subsequent edition of the Summer Paralympics, but never in the Winter Paralympics. Its delegations have always been small, never consisting in more than three competitors.
Uruguay's only medal, to date, was a bronze won by Jorge Llerena in the men's 200m sprint (T10 category) in 1996. Llerena ran the final in 24.28s, behind a Spanish and a British competitor.
||Men's 200 m T10
||heats: 24.49s (2nd in heat 3)
semi-finals: 24.32s (2nd in heat 2)