User:CopperKettle

From Wikipedia, the free encyclopedia
Kettle info
en-3This user can contribute with an advanced level of English.
ruРусскийродной язык этого участника.
This user has a page on Wiktionary.
This user contributes to the Neuroscience WikiProject.
This user is a participant in WikiProject Russia.
This user is a Citizen of the World (Terra, ).
This user believes that all men are created equal.
This user supports the United Nations.
This user supports immigration and the right to travel freely upon the planet we share.
LJThis user maintains a LiveJournal  as @copperkettle78.
USSR
USSR
I was born in the USSR.
This user is against communism.
Yo-burg city
CopperKettle is there somewhere
This user listens to Frank Zappa.
This user enjoys the works of
Truman Capote.
This user enjoys the works of
Isaac Asimov.
KV This user enjoys
the works of
Kurt Vonnegut.

George Orwell taught this user everything they need to know about the government.
FreThis user is a Fremen.
This user has Keratoconus.


This user has an interest in diabetes.
This user is interested in Peak Oil Theory.

I live in Ekaterinburg, Russia. As of 2019, I'm a freelance translator specializing in biochem, biotech and pharma. My interests include psychiatry and neuroscience. And history of Russia.

I love the music of Bob Dylan, Boris Grebenshikov (Aquarium), Frank Zappa, Chumbawamba, Umka and Beethoven's string quartets. I enjoy skiing and jogging, playing tennis.

My favourite authors are Solzhenitsyn, Updike, Pelevin, Dostoyevsky, Vonnegut.

I participate in the Folding@home project. My last.fm account is here.

My Wikimedia page.


P.S. Reelin' cookies: If you know a foreign language into which Reelin is not yet translated, start a stub - and I will give you a cookie.

Pages I've started (about 149 thus far)[edit]

In no particular order, but generally newest up:

Articles To Start[edit]

SYNGAP1 gene
CC-BY review, 2018, PMID 29402231
What's the role of L-arginine?
Review - CC-BY
Rather high impact factor
Assoc w/neurodevelopmental disorder
Translate to Russian
"CblE type"
used in phrases like HoloTC assay
Also known as Non-ketotic hyperglycaemic seizures
Or Hypomyelinating leukodystrophies - see a 2020 review
PMID: 37419197 DOI: 10.1016/j.envres.2023.116528
- related to Orphan gene?
See Resolvin
They include Mabry syndrome; their number is estimated at 19 or 21
Article in The Guardian, 2023
Reviewed in PMID 28144933
Amazing case in PMID 8683509 (misdiagnosed as psychiatric for 10 years, then cured)
-- as a standalone from Ketogenic diet
Or as part of Insulin autoimmune syndrome (exists)?
"In a group of healthy adults, those who practiced high-resistance IMST for 30 breaths a day for six weeks saw their systolic blood pressure—the first number in a reading—drop by 9 millimeters of mercury"
Folate supplementation prevents cognitive decline in mouse model (curious)
Signs of putative folate deficiency in patients (see OMIM)
Psychologist, author of books, Uni of Toronto
In some: "psychiatric abnormalities, including depression, bipolar disorder, hallucinations, aggressive behavior, and suicide attempts" (see OMIM)
Might be assoc w/depression
(2021)(REVIEW)(CC-BY) Iron, neuro-bioavailability and depression in eJHaem (IF: 4)
OMIM 617788
linked to autism
CC-BY images
2021 review on Shankopathies in autism
Corrected with folinic acid: case report 2022
"miR483-5p/Pgap2 pathway regulates anxiety"
OMIM 620144, gene: CACNAC1I
This gene is assoc with both SZ and OCD
"common in early stage bvFTD, arising prior to cognitive and neuroanatomic changes" (Christopher Morrow et al., 2022)
SLC30A9 gene
Ameliorated by lipoic acid, presumably
"prednisolone should provide a more valid test of the HPA axis in depression" (Juruena et al 2018)
Discovered galanin
as a standalone
As a separate page?
mir-184, assoc w/keratoconus
Assoc w/keratoconus
In Glutathione defiency (transient, for instance, with acetaminophen)
Detection of Riboflavin deficiency
redox/inflammation
The list in this review
Into a separate article. Riboflavin as treatment
FGF3 gene
CC-BY Review 2020
Leukoencephalopathy with thalamus and brainstem involvement and high lactate
  • EARS2 gene, mitochondrial enzyme
Defects found in 2 patients with CFD
Blunted in schizophrenia, linked to arachidonic acid pathway
Obesity, inflammation
A form of Ohtahara syndrome?
OMIM 614671
OMIM 614688
Huntingtin gene hypofunction
Write more
Autistic features
rare but curious
Could be assoc w/schizophrenia via rs72657988
Assoc w/psych disorders in offsprings
any link to folate metabolism?
Decreased in SZ, Bipolar
Gene CHD8
putative: inflammation triggered in blood by the cardio-lung-bypass machine
Investigated in ALZ's Disease, Parkinson's
TIAM1 gene
Pregnenolone derivative; might be used in alcoholism
Lasosamide - induced psychosis case
CRMP2 and betaine? O_O
OMIM 617744
Gene - NRF2, related to keratoconus
??CSF-venous fistula - source
2022 Review of numerous genes/causes: PMID 35328062 (CC-BY 4.0)
Gene: TYROBP
Putative neuroprotection in Parkinson's; counters inflammatory cytokine signaling
OMIM 619575
gene - TAOK1
Prompted by a report on a psych forum of depression/halluc. of a guy on cyprofloxacine
Example review (2020) in PubMed
Gene: WDR45
On withdrawal of dopamine medication
CC-BY 2022 review in Cureus
Gene: KDM6B, could be associated with CFD
Mutations in CDC42 which affects dendritic spines
Linked to Early-onset vitamin B6-dependent epilepsy (OMIM 617290)
Is it worth reading? (example article)
convert to standalone?
Muscarinic, for schizophrenia
Includes malondialdehyde, elevated in keratoconus serum
First to attempt DBS in Parkinson's
Autism and other manifestations; one of the genes: CYFIP1
Two OMIM numbers: 613444 and 611913
Alpha-aminoadipic semialdehyde
of the book "Plague Cycle"
Possible target of methotrexate in psoriasis
Mutations in CAMKIIα
Autism spectrum
and ODC1 disorder - distinct?
see myoclonic astatic epilepsy, aka Doose syndrome
the RAC3 gene
ACAD9
Gene: MRE11A
protein that might be useful in diabetes
For instance, in deficiency of the mitochondrial folate transporter
NSAID-induced
gene: ATP2B1
Mutations in the gene might be associated with BH4 deficiency in refractory depression, per Lisa Pan et al., 2020
Variants found in patients with refractory depression and BH4 deficiency by Lisa Pan et al., PMID 32128872
The same snp rs79258645 as in Lisa Pan et al is associated w/keratoconus Layal Fadi Abi Farraj, 2015
Mutations in NR4A2
Exists in German Wikipedia
To distinguish Cushing's from Pseudo-Cushing's
Deficient serine transport into the brain
Disfunction in cerebral folate deficiency
Reviews: 2019 with mention of CFD
See, for instance, table 1 here or a similar table in this CC-BY review (2021)
See Pyridoxine 5′-phosphate oxidase
Possible use in depression: review
  • ?Folate trap in folate metabolism
  • ?Oculomics - research of eye-based biomarkers of non-ophthalmological pathology
Schizophrenia in Translation: Why the Eye?
Mutations in TUBB4A
Might be associated with cerebral folate deficiency
accompanied by cerebral folate deficiency? Folinic acid helps, per PMID 31340680 (review)
" is the second most common of the known inherited disorders of folate metabolism" 18 cases
  • Navajo neurohepatopathy (NNH; 256810)
extremely strange Luft's disease
  • The disorder has received several names, including acute diffuse lymphocytic meningoencephalitis,2,3 acute reversible limbic encephalitis,4 acute juvenile female nonherpetic encephalitis,1 or juvenile acute nonherpetic encephalitis.

(see Felix Jacob Marchand)
see PMID 11739428 (high-prev. in CAH)
see a review of rests in CAH
(Cochet-Bonnet aesthesiometer )

Articles to expand and improve[edit]

  • Secondary predicate
  • Rickets - if "Magnesium-dependent vitamin-D-resistant rickets" is a real thing, add a mention.
  • Antiphospholipid syndrome - add info on psychiatric presentations (antibodies to annexins? Annexins are linked to p11, which is implicated in depression)

Articles to improve:[edit]

Would be great to translate:[edit]

  • Into Russian:
Endocrinology:
Ukrainian music:
Psychiatry etc.:
For depression/anxiety
  • P11 for its role in depression.
  • PON1 together with MTHFR affects 5-MTHF metabolism, may be protective in schizophrenia by increasing CSF 5-MTHF
Authors:
Studied DHPR defiency in 1975-2000 (2016 review)
Nitric oxide a culprit (NO also involved in autism?)
May be compounded by oxitocin deficiency, causing anxiety
Also improve: add info on falsely elevated free urine 24h cortisol
Curious 2023 meta-analysis
GABA breakdown inhibitor
Assoc with keratoconus
Metabolism changed in depression, other disorders

Articles I've contributed to[edit]

Acceptability of sources in medical articles[edit]

Questionable sources[edit]

Useful pages, FAQs[edit]

Tools for protein infobox[edit]

First get HGNCID here, next populate using this tool here.

commons:User:CopperKettle[edit]

I assert to be the same user as commons:User:CopperKettle --CopperKettle 14:03, 22 February 2007 (UTC)

Les Encyclopédistes[edit]

Interesting stuff[edit]

Music to check out[edit]

Interesting folk[edit]

Subpages[edit]